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Database: UniProt
Entry: H2RCB4_PANTR
LinkDB: H2RCB4_PANTR
Original site: H2RCB4_PANTR 
ID   H2RCB4_PANTR            Unreviewed;      4865 AA.
AC   H2RCB4; A0A2J8JB45;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   23-MAY-2018, entry version 45.
DE   SubName: Full=RYR3 isoform 2 {ECO:0000313|EMBL:PNI19991.1};
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSPTRP00000057052};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSPTRP00000057052,
GN   ECO:0000313|VGNC:VGNC:1882};
GN   ORFNames=CK820_G0049126 {ECO:0000313|EMBL:PNI19991.1};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000057052, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000057052, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000057052}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:PNI19991.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI19991.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:PNI19991.1};
RA   Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
RA   Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
RA   Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
RA   Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
RA   Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
RA   Haussler D., Eichler E.;
RT   "High-resolution comparative analysis of great ape genomes.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AACZ04060381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04060382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04060383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04060384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04060385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; NBAG03000487; PNI19991.1; -; Genomic_DNA.
DR   RefSeq; XP_016783379.1; XM_016927890.1.
DR   STRING; 9598.ENSPTRP00000057052; -.
DR   PaxDb; H2RCB4; -.
DR   Ensembl; ENSPTRT00000065488; ENSPTRP00000057052; ENSPTRG00000006872.
DR   GeneID; 453296; -.
DR   CTD; 6263; -.
DR   VGNC; VGNC:1882; RYR3.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H2RCB4; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000002277; Chromosome 15.
DR   Bgee; ENSPTRG00000006872; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 6.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4178   4202       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4406   4426       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4474   4493       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4605   4623       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4666   4687       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4746   4769       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    269       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      275    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      585    796       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1012   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1254   1466       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3914   3949       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      459    479       {ECO:0000256|SAM:Coils}.
FT   COILED     3219   3239       {ECO:0000256|SAM:Coils}.
FT   COILED     4328   4355       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4865 AA;  551581 MW;  57CE655E7B818407 CRC64;
     MAEGGEGGED EIQFLRTEDE VVLQCIATIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP
     PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH RTLLYGHAVL LRHSFSGMYL
     TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER
     YLHLSVSNGN IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD
     QNDSQHRRIF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
     QGLILQDRAK SDTKSTAFSF RASKELKEKL DSSHKRDIEG MGVPEIKYGD SVCFVQHIAS
     GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QREESQAARI IRNTTALFSQ
     FVSGNNRTAA PITLPIEEVL QTLQDLIAYF QPPEEEMRHE DKQNKLRSLK NRQNLFKEEG
     MLALVLNCID RLNIYNSVAH FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN
     NLDWLISKLD RLESSSGILE VLHCILTESP EALNLIAEGH IKSIISLLDK HGRNHKVLDI
     LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSAQYKKW
     YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW
     SGRIPRAVAS INQHLLRSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS
     FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGIRDLLGT
     TQFLSQASFI PCPVDTSQVV LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR
     QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS
     NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV
     PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD SAVEKVSIDK IRFFRVERSY
     AVRSGKWYFE FEVVTGGDMR VGWARPGCRP DVELGADDQA FVFEGNRGQR WHQGSGYFGR
     TWQPGDVVGC MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CCLGLSQIGR
     MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD HPHIEVMRID
     GTMDSPPCLK VTHKTFGTQN SNADMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI
     LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE
     SVKRSNCYMV WGGDIVASSQ RSNRSNVDLE IGCLVDLAMG MLSFSANGKE LGTCYQVEPN
     TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFRSEEK NPVPQCPPRL DVQTIQPVLW
     SRMPNSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMRFHYH
     TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF YAIDNKYLPG LLRSGFYDLL ISIHLANAKE
     RKLMMKNEYI IPITSTTRNI RLFPDESKRH GLPGVGLRTC LKPGFRFSTP CFVVTGEDHQ
     KQSPEIPLES LRTKALSMLT EAVQCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD
     DDVRQILLLI DPSVFGEHSA GTEEGAEKEE VTQVEEKAVE AGEKAGKEAP VKGLLQTRLP
     ESVKLQMCEL LSYLCDCELQ HRVEAIVAFG DIYVSKLQAN QKFRYNELMQ ALNMSAALTA
     RKTKEFRSPP QEQINMLLNF QLGENCPCPE EIREELYDFH EDLLLHCGVP LEEEEEEEED
     TSWTGKLCAL VYKIKGPPKP EKEQPTEEEE RCPTTLKELI SQTMICWAQE DQIQDSELVR
     MMFNLLRRQY DSIGELLQAL RKTYTISHTS VSDTINLLAA LGQIRSLLSV RMGKEEELLM
     INGLGDIMNN KVFYQHPNLM RVLGMHETVM EVMVNVLGTE KSQIAFPKMV ASCCRFLCYF
     CRISRQNQKA MFEHLSYLLE NSSVGLASPS MRGSTPLDVA ASSVMDNNEL ALSLEEPDLE
     KVVTYLAGCG LQSCPMLLAK GYPDVGWNPI EGERYLSFLR FAVFVNSESV EENASVVVKL
     LIRRPECFGP ALRGEGGNGL LAAMQGAIKI SENPALDLPS QGYKREVSTE DDEEEEEIVH
     MGNAIMTFYS ALIDLLGRCA PEMHLIQTGK GEAIRIRSIL RSLVPTEDLV GIISIPLKLP
     SLNKDGSVSE PDMAANFCPD HKAPMVLFLD RVYGIKDQTF LLHLLEVGFL PDLRASASLD
     TVSLSTTEAA LALNRYICSA VLPLLTRCAP LFAGTEHCTS LIDSTLQTIY RLSKGRSLTK
     AQRDTIEECL LAICNHLRPS MLQQLLRRLV FDVPQLNEYC KMPLKLLTNH YEQCWKYYCL
     PSGWGSYGLA VEEELHLTEK IFWGIFDSLS HKKYDPDLFR MALPCLSAIA GALPPDYLDT
     RITATLEKQI SVDADGNFDP KPINTMNFSL PEKLEYIVTK YAEHSHDKWA CDKSQSGWKY
     GISLDENVKT HPLIRPFKTL TEKEKEIYRW PARESLKTML AVGWTVERTK EGEALVQQRE
     NEKLRSVSQA NQGNSYSPAP LDLSNVVLSR ELQGMVEVVA ENYHNIWAKK KKLELESKGG
     GSHPLLVPYD TLTAKEKFKD REKAQDLFKF LQVNGIIVSR GMKDMELDAS SMEKRFAYKF
     LKKILKYVDS AQEFIAHLEA IVSSGKTEKS PHDQEIKFFA KVLLPLVDQY FTNHCLYFLS
     SPLKPLSSSG YASHKEKEMV ASLFCKLAAL VRHRISLFGS DSTTMVSCLH ILAQTLDTRT
     VMKSGSELVK AGLRAFFENA AEDLEKTSEN LKLGKFTHSR TQIKGVSQNI NYTTVALLPI
     LTSIFEHVTQ HQFGMDLLLG DVQISCYHIL CSLYSLGTGK NIYVERQRPA LGECLASLAA
     AIPVAFLEPT LNRYNPLSVF NTKTPRERSI LGMPDTVEDM CPDIPQLEGL MKEINDLAES
     GARYTEMPHV IEVILPMLCN YLSYWWERGP ENLPPSTGPC CTKVTSEHLS LILGNILKII
     NNNLGIDEAS WMKRIAVYAQ PIISKARPDL LRSHFIPTLE KLKKKAVKTV QEEEQLKADG
     KGDTQEAELL ILDEFAVLCR DLYAFYPMLI RYVDNNRSNW LKSPDADSDQ LFRMVAEVFI
     LWCKSHNFKR EEQNFVIQNE INNLAFLTGD SKSKMSKSGG QDQERKKTKR RGDLYSIQTS
     LIVAALKKML PIGLNMCTPG DQELISLAKS RYSHRDTDEE VREHLRNNLH LQEKSDDPAV
     KWQLNLYKNV LKSEEPFNPE KTVERVQRIS AAVFHLEQVE QPLRSKKAVW HKLLSKQRKR
     AVVACFRMAP LYNLPRHRSI NLFLHGYQRF WIETEEYSFE EKLVQDLAKS PKVEEEEEEE
     TEKQPDPLHQ IILYFSRNAL TERSKLEDDP LYTSYSSMMA KSCQSGEDEE EDEDKEKTFE
     EKEMEKQKTL YQQARLHERG AAEMVLQMIS ASKGEMSPMV VETLKLGIAI LNGGNAGVQQ
     KMLDYLKEKK DAGFFQSLSG LMQSCSVLDL NAFERQNKAE GLGMVTEEGT LIVRERGEKV
     LQNDEFTCDL FRFLQLLCEG HNSDFQNFLR TQMGNTTTVN VIISTVDYLL RLQESISDFY
     WYYSGKDIID ESGQHNFSKA LAVTKQIFNS LTEYIQGPCI GNQQSLAHSR LWDAVVGFLH
     VFANMQMKLS QDSSQIELLK ELLDLLQDMV VMLLSLLEGN VVNGTIGKQM VDTLVESSTN
     VEMILKFFDM FLKLKDLTSS DTFKEYDPDG KGIISKKEFQ KAMEGQKQYT QSEIDFLLSC
     AEADENDMFN YVDFVDRFHE PAKDIGFNVA VLLTNLSEHM PNDSRLKCLL DPAESVLNYF
     EPYLGRIEIM GGAKKIERVY FEISESSRTQ WEKPQVKESK RQFIFDVVNE GGEQEKMELF
     VNFCEDTIFE MQLASQISES DSADRPEEEE EDEDSSYVLE IAGEEEEDGS LEPASAFAMA
     CASVKRNVTD FLKRATLKNL RKQYRNVKKM TAKELVKVLF SFFWMLFVGL FQLLFTILGG
     IFQILWSTVF GGGLVEGAKN IRVTKILGDM PDPTQFGIHD DTMEAERAEV MEPGITTELV
     HFIKGEKGDT DIMSDLFGLH PKKEGSLKHG PEVGLGDLSE IIGKDEPPTL ESTVQKKRKA
     QAAEMKAANE AEGKVESEKA DMEDGEKEDK DKEEEQAEYL WTEVTKKKKR RCGQKVEKPE
     AFTANFFKGL EIYQTKLLHY LARNFYNLRF LALFVAFAIN FILLFYKVTE EPLEEETEDV
     ANLWNSFNDE EEEEAMVFFV LQESTGYMAP TLRALAIIHT IISLVCVVGY YCLKVPLVVF
     KREKEIARKL EFDGLYITEQ PSEDDIKGQW DRLVINTPSF PNNYWDKFVK RKVINKYGDL
     YGAERIAELL GLDKNALDFS PVEETKAEAA SLVSWLSSID MKYHIWKLGV VFTDNSFLYL
     AWYTTMSVLG HYNNFFFAAH LLDIAMGFKT LRTILSSVTH NGKQLVLTVG LLAVVVYLYT
     VVAFNFFRKF YNKSEDDDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE DPAGDPYEMY
     RIVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVRE DMETKCFICG IGNDYFDTTP
     HGFETHTLQE HNLANYLFFL MYLINKDETE HTGQESYVWK MYQERCWDFF PAGDCFRKQY
     EDQLG
//
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