ID H2RD10_PANTR Unreviewed; 544 AA.
AC H2RD10; A0A2J8IMK6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Zinc finger protein 891 {ECO:0000313|Ensembl:ENSPTRP00000058148.2};
GN Name=ZNF891 {ECO:0000313|Ensembl:ENSPTRP00000058148.2,
GN ECO:0000313|VGNC:VGNC:14423};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000058148.2, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000058148.2, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000058148.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC {ECO:0000256|ARBA:ARBA00003767}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; AACZ04060466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003314095.1; XM_003314047.4.
DR RefSeq; XP_016780247.1; XM_016924758.1.
DR AlphaFoldDB; H2RD10; -.
DR PaxDb; 9598-ENSPTRP00000058148; -.
DR Ensembl; ENSPTRT00000066570.3; ENSPTRP00000058148.2; ENSPTRG00000034499.3.
DR GeneID; 100610530; -.
DR KEGG; ptr:100610530; -.
DR CTD; 101060200; -.
DR VGNC; VGNC:14423; ZNF891.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164587; -.
DR HOGENOM; CLU_002678_0_9_1; -.
DR InParanoid; H2RD10; -.
DR OMA; QHKIPEG; -.
DR OrthoDB; 458400at2759; -.
DR TreeFam; TF337055; -.
DR Proteomes; UP000002277; Chromosome 12.
DR Bgee; ENSPTRG00000034499; Expressed in pituitary gland and 21 other cell types or tissues.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23226:SF317; RCG31665-RELATED; 1.
DR PANTHER; PTHR23226; ZINC FINGER AND SCAN DOMAIN-CONTAINING; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF13465; zf-H2C2_2; 3.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 43..113
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 320..347
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 348..375
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 376..403
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 404..431
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 432..459
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 460..487
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 488..515
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 516..543
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 544 AA; 63635 MW; 6F5743A8BC48DA46 CRC64;
MAVMDLSSPW ALTKQDSACF HLRNAEEERM IAVFLTTWLQ EPMTFKDVAV EFTQEEWMML
DSAQRSLYRD VMLENYRNLT SVEYQLYRLT VISPLDQEEI RNMKKRIPQA ICPDQKIQPK
TKESTVQKIL WEEPSNAVKM IKLTMHNWSS TLREDWECHK IRKQHKIPGG HWRQMTYAPN
KTVSQELFRD YHELEENSKL RSKLIFSQSI FTSKHCQKCY SEIGCLKHNS IINNYVKNSI
SEKLYESHEC DTTLWHLQRN QTVQKEYTYS KHGMHFTHNM FPVPNNLHMA QNACECNKDE
TLCHQSSLKK QGQTHTEKKH ECNQCGKAFK RISNLTLYKK SHMGEKQYEC KECGKVFNDS
STLRRHVRTH TGEKPYECNQ CGKAFSQKTS LKAHMRTHTG EKPYECNQCG KSFGTSSYLI
VHKRIHTGEK LYECSECGKA FNTSSHLKVH KKIHTGENLY ECSDCGKVFS GVSSLRMHIR
THTGEKPYEC KECRKAFSVS SSLRRHVRIH TGEKPYECIQ CGKAFSQSSS LIIHKRIHTE
RETL
//
