ID H2RD98_PANTR Unreviewed; 730 AA.
AC H2RD98; A0A2J8PTQ3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Triadin {ECO:0000256|ARBA:ARBA00016711};
GN Name=TRDN {ECO:0000313|Ensembl:ENSPTRP00000058505.3,
GN ECO:0000313|VGNC:VGNC:52147};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000058505.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000058505.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000058505.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC Sarcoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004157};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004157}.
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DR EMBL; AACZ04054388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04054389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04054390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04054391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016811747.1; XM_016956258.1.
DR AlphaFoldDB; H2RD98; -.
DR STRING; 9598.ENSPTRP00000058505; -.
DR Ensembl; ENSPTRT00000066928.3; ENSPTRP00000058505.3; ENSPTRG00000018567.6.
DR GeneID; 744745; -.
DR KEGG; ptr:744745; -.
DR CTD; 10345; -.
DR VGNC; VGNC:52147; TRDN.
DR eggNOG; ENOG502S0X4; Eukaryota.
DR GeneTree; ENSGT00510000049207; -.
DR HOGENOM; CLU_023557_0_0_1; -.
DR InParanoid; H2RD98; -.
DR OMA; QIHKQDI; -.
DR OrthoDB; 5363225at2759; -.
DR TreeFam; TF350396; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000018567; Expressed in skeletal muscle tissue and 11 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0014701; C:junctional sarcoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0060047; P:heart contraction; IBA:GO_Central.
DR GO; GO:0086036; P:regulation of cardiac muscle cell membrane potential; IBA:GO_Central.
DR GO; GO:0010880; P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR InterPro; IPR010798; Triadin.
DR PANTHER; PTHR14106; TRIADIN; 1.
DR PANTHER; PTHR14106:SF0; TRIADIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..131
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..300
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 81779 MW; D06C8C952D05E71D CRC64;
MTEITAEGNA STTTTVIDSK NGSVPKSPGK VLKRTVTEDI VTTFSSPAAW LLVIALIITW
SAVAIVMFDL VDYKNFSASS IAKIGSDPLK LVRDAVEETT DWIYGFFSLL SDIISSEDED
DDDGDEDTDK GEIDEPPLRK KEIHKDKTEK QEKPERKIQT KVTHKEKEKE KEKVREKEKP
EKKATHKEKI EKKEKPETKT VAKEQKKAKT AEKSEEKTKK EVKGGKQEKV KQTAAKVKEV
QKTPSKPKEK EDKEKAAVSK HEQKDQYAFC RYMIDIFVHG DLKPGQSPAI PPPLPTEQAS
RPTPASPALE EKEGEKKKAE KKVTSETKKK EKEDVKKKSE KETAIDVEKK EPGKASETKQ
GTVKIAAQAA AKKDEKKEDS KKTKKPAEVE QPKGKKQEKK EKHVEPAKSP KKEHSVPSEK
QVKAKTERAK EEIGAVSSKK AVPGKKEEKT TKTVEQEIRK EKSGKTSSIL KDKEPIKGKE
EKVPASLKEK EPETKKDEKM SKAGKEVKPK PPQLQGKKEE KPEPQIKKEA KPAISEKVQI
HKQDIVKPEK TVPHGKPEEK VLKQVKAVTI EKTAKPKPTK KAEHRERELP SIKTDKPKPT
PKGTSEVTES GKKKTEISEK ESKEKADMKH LKEEKVSTRK ESLQLHNVTK AEKPARVSKD
VEDVPASKKA KEETEDVSPT KKQKSPISFF QCVYLDGYNG YGFQFPFTPA DRPGESSGQA
NSPGQKQQGQ
//
