ID H2RDG2_PANTR Unreviewed; 852 AA.
AC H2RDG2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Neural cell adhesion molecule 1 {ECO:0000313|Ensembl:ENSPTRP00000058793.3};
GN Name=NCAM1 {ECO:0000313|Ensembl:ENSPTRP00000058793.3,
GN ECO:0000313|VGNC:VGNC:3080};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000058793.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000058793.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000058793.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: This protein is a cell adhesion molecule involved in neuron-
CC neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
CC {ECO:0000256|ARBA:ARBA00003000}.
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DR EMBL; AACZ04006776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04006777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04006778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04006779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04006780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2RDG2; -.
DR Ensembl; ENSPTRT00000063512.4; ENSPTRP00000058793.3; ENSPTRG00000004291.6.
DR VGNC; VGNC:3080; NCAM1.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000155743; -.
DR HOGENOM; CLU_010961_0_0_1; -.
DR TreeFam; TF326195; -.
DR Proteomes; UP000002277; Chromosome 11.
DR Bgee; ENSPTRG00000004291; Expressed in dorsolateral prefrontal cortex and 20 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05865; IgI_1_NCAM-1; 1.
DR CDD; cd05869; IgI_NCAM-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR009138; Neural_cell_adh.
DR PANTHER; PTHR12231; CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN; 1.
DR PANTHER; PTHR12231:SF239; NEURAL CELL ADHESION MOLECULE 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR PRINTS; PR01838; NCAMFAMILY.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..852
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014125885"
FT TRANSMEM 717..740
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..115
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 120..193
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 216..305
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 312..407
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 410..495
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 503..602
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 604..700
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 760..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..802
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..829
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 852 AA; 94161 MW; F964B95A99BAFFCB CRC64;
MFELNFVFFV LFFVLFCFVF SVSLQVDIVP SQGEISVGES KFFLCQVAGD AKDKDISWFS
PNGEKLTPNQ QRISVVWNDD SSSTLTIYNA NIDDAGIYKC VVTGEDGSES EATVNVKIFQ
KLMFKNAPTP QEFREGEDAV IVCDVVSSLP PTIIWKHKGR DVILKKDVRF IVLSNNYLQI
RGIKKTDEGT YRCEGRILAR GEINFKDIQV IVNVPPTIQA RQNIVNATAN LGQSVTLVCD
AEGFPEPTMS WTKDGEQIEQ EEDDEKYIFS DDSSQLTIKK VDKNDEAEYV CIAENKAGEQ
DATIHLKVFA KPKITYVENQ TAMELEEQVT LTCEASGDPI PSITWRTSTR NISSEEKTLD
GHMVVRSHAR VSSLTLKSIQ YTDAGEYICT ASNTIGQDSQ SMYLEVQYAP KLQGPVAVYT
WEGNQVNITC EVFAYPSAMI SWFRDGQLLP SSNYSNIKIY NTPSASYLEV TPDSENDFGN
YNCTAVNRIG QESLEFILVQ ADTPSSPSID QVEPYSSTAQ VQFDEPEATG GVPILKYKAE
WRAVGEEVWH SKWYDAKEAS MEGIVTIVGL KPETTYAVRL AALNGKGLGE ISAASEFKTQ
PVREPSAPKL EGQMGEDGNS IKVNLIKQDD GGSPIRHYLV RYRAKLSSEW KPEIRLPSGS
DHVMLKSLDW NAEYEVYVVA ENQQGKSKAA HFVFRTLAQP TAIPANGSPT SGLSTGAIVG
ILIVIFVLLL VIVDITCYFL NKCGLFMCIA VNLCGKAGPG AKGKDMEEGK AAFSKDESKE
PIVEVRTEEE RTPNHDGGKH TEPNETTPLT EPEKGPVEAK PECQETETKP APAEVKTVPN
DATQTKENES KA
//
