ID H2RDW0_PANTR Unreviewed; 1042 AA.
AC H2RDW0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=GNAS complex locus {ECO:0000313|Ensembl:ENSPTRP00000059419.3};
GN Name=GNAS {ECO:0000313|Ensembl:ENSPTRP00000059419.3,
GN ECO:0000313|VGNC:VGNC:57986};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000059419.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000059419.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000059419.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(s) subfamily.
CC {ECO:0000256|ARBA:ARBA00007172}.
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DR EMBL; AACZ04052922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2RDW0; -.
DR PaxDb; 9598-ENSPTRP00000059419; -.
DR Ensembl; ENSPTRT00000067830.3; ENSPTRP00000059419.3; ENSPTRG00000032488.4.
DR VGNC; VGNC:57986; GNAS.
DR eggNOG; KOG0099; Eukaryota.
DR GeneTree; ENSGT00940000156300; -.
DR HOGENOM; CLU_010619_0_0_1; -.
DR InParanoid; H2RDW0; -.
DR TreeFam; TF300673; -.
DR Proteomes; UP000002277; Chromosome 20.
DR Bgee; ENSPTRG00000032488; Expressed in dorsolateral prefrontal cortex and 20 other cell types or tissues.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0010856; F:adenylate cyclase activator activity; IEA:Ensembl.
DR GO; GO:0031698; F:beta-2 adrenergic receptor binding; IBA:GO_Central.
DR GO; GO:0051430; F:corticotropin-releasing hormone receptor 1 binding; IBA:GO_Central.
DR GO; GO:0031748; F:D1 dopamine receptor binding; IBA:GO_Central.
DR GO; GO:0003925; F:G protein activity; IEA:Ensembl.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0005159; F:insulin-like growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0035255; F:ionotropic glutamate receptor binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031852; F:mu-type opioid receptor binding; IBA:GO_Central.
DR GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0071377; P:cellular response to glucagon stimulus; IEA:Ensembl.
DR GO; GO:0006306; P:DNA methylation; IEA:Ensembl.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
DR GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
DR GO; GO:0006112; P:energy reserve metabolic process; IEA:Ensembl.
DR GO; GO:0071514; P:genomic imprinting; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0040032; P:post-embryonic body morphogenesis; IEA:Ensembl.
DR GO; GO:2000828; P:regulation of parathyroid hormone secretion; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IBA:GO_Central.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR GO; GO:0001894; P:tissue homeostasis; IEA:Ensembl.
DR CDD; cd00066; G-alpha; 1.
DR CDD; cd22249; UDM1_RNF168_RNF169-like; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000367; Gprotein_alpha_S.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF348; GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) SUBUNIT ALPHA ISOFORMS XLAS; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00443; GPROTEINAS.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..671
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1042 AA; 111412 MW; C00A98D8AC1BF769 CRC64;
MGMRNCLYGN NMSGQRDIPP EIGEQPEQPP LEAPGATAPG AGPSPAEEME TEPPHNEPIP
IENDGEACGP PEVSRPNFQV LNPAFREAGA HGSYSPPPEE AMPFEVEQPS LGGFWPTLEQ
PGFPSGVHAG LEAFGPALME PGAFSGARPG LGGYSPPPEE AMPFEFDQPA QRGCSQLLLQ
VPDLAPGGPG AAGVPGAPPE EPQALRPAKA GSRGGYSPPP EETMPFELDG EGFGDDSPPP
GLSRVIAQVD GSGQFAAVAA SSAVRLTPAA NAPPLWVPGA IGSPSQEAVR PPSNFTGSSP
WMEISGPPFE IGSAPAGVDD TPVNMDSPPI ALDGPPIKVS GAPDKRERAE RPPVEEEAAE
MEGAADAAEG GKVPSPGYGS PAAGAASADT AAGAASADTA ARAAPAAPAD PDSGATPEDP
DSGTAPADPD SGAAPADPDS GAAPAAPADP DSGAAPDAPA DPDSGAAPDA PADPDSGAPA
APAAAETRAA HVAPAAPDAG APTAPAASAT RAAQVRRAAS AAPASGARRK IHLRPPSPEI
QAADPPTPRP TRASAWRGKS ESSRGRRVYY DEGVASSDDD SSGDESDDGT SGCLRWFQHR
RNRRRRKPQR NLLRNFLVQA FGGCFGRSES PQPKASRSLK VKKVPLAEKR RQMRKEALEK
RAQKRAEKKR SKLIDKQLQD EKMGYMCTHR LLLLGAGESG KSTIVKQMRI LHVNGFNGEG
GEEDPQAARS NSDGEKATKV QDIKNNLKEA IETIVAAMSN LVPPVELANP ENQFRVDYIL
SVMNVPDFDF PPEFYEHAKA LWEDEGVRAC YERSNEYQLI DCAQYFLDKI DVIKQADYVP
SDQDLLRCRV LTSGIFETKF QVDKVNFHMF DVGGQRDERR KWIQCFNDVT AIIFVVASSS
YNMVIREDNQ TNRLQEALNL FKSIWNNRWL RTISVILFLN KQDLLAEKVL AGKSKIEDYF
PEFARYTTPE DATPEPGEDP RVTRAKYFIR DEFLRISTAS GDGRHYCYPH FTCAVDTENI
RRVFNDCRDI IQRMHLRQYE LL
//
