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Database: UniProt
Entry: H2RE26_PANTR
LinkDB: H2RE26_PANTR
Original site: H2RE26_PANTR 
ID   H2RE26_PANTR            Unreviewed;       451 AA.
AC   H2RE26;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   16-OCT-2019, entry version 65.
DE   SubName: Full=ETS transcription factor ERG {ECO:0000313|Ensembl:ENSPTRP00000059760};
GN   Name=ERG {ECO:0000313|Ensembl:ENSPTRP00000059760,
GN   ECO:0000313|VGNC:VGNC:14662};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000059760, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000059760, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000059760, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000059760}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; AACZ04064319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000059760; -.
DR   Ensembl; ENSPTRT00000068163; ENSPTRP00000059760; ENSPTRG00000013907.
DR   VGNC; VGNC:14662; ERG.
DR   eggNOG; KOG3806; Eukaryota.
DR   eggNOG; ENOG410Z0ZF; LUCA.
DR   GeneTree; ENSGT00940000160662; -.
DR   TreeFam; TF350537; -.
DR   Proteomes; UP000002277; Chromosome 21.
DR   Bgee; ENSPTRG00000013907; Expressed in 6 organ(s), highest expression level in heart.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT   DOMAIN      109    195       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      283    363       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION       30     52       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION       68     88       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      213    274       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    235    257       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   451 AA;  50870 MW;  A76F9EE217D96967 CRC64;
     IQEALSVVSE DQSLFECAYG TPHLAKTEMT ASSSSDYGQT SKMSPRVPQQ DWLSQPPARV
     TIKMECNPSQ VNGSRNSPDE CSVAKGGKMV GSPDTVGMNY GSYMEEKHMP PPNMTTNERR
     VIVPADPTLW STDHVRQWLE WAVKEYGLPD VNILLFQNID GKELCKMTKD DFQRLTPSYN
     ADILLSHLHY LRETPLPHLT SDDVDKALQN SPRLMHARNT DLPYEPPRRS AWTGHGHPTP
     QSKAAQPSPS TVPKTEDQRP QLDPYQILGP TSSRLANPGS GQIQLWQFLL ELLSDSSNSS
     CITWEGTNGE FKMTDPDEVA RRWGERKSKP NMNYDKLSRA LRYYYDKNIM TKVHGKRYAY
     KFDFHGIAQA LQPHPPESSL YKYPSDLPYM GSYHAHPQKM NFVAPHPPAL PVTSSSFFAA
     PNPYWNSPTG GIYPNTRLPT SHMPSHLGTY Y
//
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