ID   H2REI6_PANTR            Unreviewed;       426 AA.
AC   H2REI6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=TRIM49 {ECO:0008006|Google:ProtNLM};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000059923.2, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000059923.2, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000059923.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AACZ04016375; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H2REI6; -.
DR   Ensembl; ENSPTRT00000075285.2; ENSPTRP00000059923.2; ENSPTRG00000052564.1.
DR   eggNOG; KOG2177; Eukaryota.
DR   GeneTree; ENSGT00940000163213; -.
DR   InParanoid; H2REI6; -.
DR   OMA; CLIYTIP; -.
DR   TreeFam; TF338674; -.
DR   Proteomes; UP000002277; Chromosome 11.
DR   Bgee; ENSPTRG00000052564; Expressed in prefrontal cortex and 1 other cell type or tissue.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   CDD; cd19783; Bbox2_TRIM43-like; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR000315; Znf_B-box.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR24103:SF613; -; 1.
DR   PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   Pfam; PF00643; zf-B_box; 1.
DR   Pfam; PF15227; zf-C3HC4_4; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00336; BBOX; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50119; ZF_BBOX; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00024}.
FT   DOMAIN          15..55
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          88..129
FT                   /note="B box-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50119"
FT   DOMAIN          244..426
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
SQ   SEQUENCE   426 AA;  49795 MW;  8FE4BE99DB57BF32 CRC64;
     MNSGILQAFQ MELTCPICMK YFIDPVTVDC GHSFCRPCFY FNWQDIPIFT RCFECMKTTW
     QRNLKTNIHL KKMASLARKV SLWLFLSSEE QMCGTHRETK KMFCEVDKSL LCLLCSSSQE
     HRYHRHRPVE WAAEEHREKL LKKMQSLWEK ACENQRNLNM ETTRISHWKD YVNLRLEAIR
     AEYEKMAAFH HEEEKHNLDM LKKKGKDIFH RLHLSKAKMA HRREILRGMY EELKEMCHKP
     DVELLQGFGD ILQRSESVLL HMPQPLNLEL SAGPITGLRD RSMCIGCDRQ NPPHITATPT
     SFLAWGAQTY TSGKYYWDVH VGDTWNWAFG VCNKYWKGKN QNGNIYGEEG LFSLGCVKND
     IQCSLFTTSP LTLQYIPRPT SHIGLFLDCE ARTVSFVDVN QSCLIYTIPN CSFSPPVRPI
     FRCVHL
//