ID H2REI9_PANTR Unreviewed; 506 AA.
AC H2REI9; A0A2J8L1I9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Lysine demethylase 4E {ECO:0000313|Ensembl:ENSPTRP00000059926.1};
GN Name=KDM4E {ECO:0000313|Ensembl:ENSPTRP00000059926.1,
GN ECO:0000313|VGNC:VGNC:11865};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000059926.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000059926.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000059926.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AACZ04006917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_522155.2; XM_522155.5.
DR AlphaFoldDB; H2REI9; -.
DR STRING; 9598.ENSPTRP00000059926; -.
DR PaxDb; 9598-ENSPTRP00000059926; -.
DR Ensembl; ENSPTRT00000075907.2; ENSPTRP00000059926.1; ENSPTRG00000041826.2.
DR GeneID; 466755; -.
DR KEGG; ptr:466755; -.
DR CTD; 390245; -.
DR VGNC; VGNC:11865; KDM4E.
DR eggNOG; KOG0958; Eukaryota.
DR GeneTree; ENSGT00940000165078; -.
DR HOGENOM; CLU_001442_6_1_1; -.
DR InParanoid; H2REI9; -.
DR OMA; LSNWRDD; -.
DR OrthoDB; 48111at2759; -.
DR TreeFam; TF106449; -.
DR Proteomes; UP000002277; Chromosome 11.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0032454; F:histone H3K9 demethylase activity; IBA:GO_Central.
DR GO; GO:0140684; F:histone H3K9me2/H3K9me3 demethylase activity; IEA:Ensembl.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR10694:SF34; LYSINE-SPECIFIC DEMETHYLASE 4E; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 15..57
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 143..309
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 432..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 506 AA; 56979 MW; 68DAF4E5D40D4A43 CRC64;
MKSVHSSPQN TSHTIMTFYP TMEEFTDFNK YVAYMESQGA HQAGLAKVIP PKEWKARQMY
DDIEDILIAT PLQQVTSGQA GVFTQYHKKK KAMTVGKYRR LANSKKYQTP PHQNFADLEQ
RYWKSHPGNP PIYGADISSS LFEESTKQWN LGHLGTILDL LEQECGVVIE GVNTPYLYFG
MWKTTFAWHT EDMDLYSINY LHFGDPKTWY VVPPEHGQHL ERLARELFPD ISRGCEAFLR
HKVALISPTV LKENGIPFNC MTQEAGEFMV TFPYGYHAGF NHGFNCAEAI NFATPRWIDY
GKMASQCSCG ESTVTFSMDP FVRIVQPESY ELWKHRQDLA IVDHTEPRVA ESQELSNWRD
DIVLRRAALG LRLLPNLTAQ CPTQPVSPGH CYNPKGCGTD AVPGSAFQSS AYHTQTQSLT
LGMSARVLLP STGSWRSGRG RGRGQGRGRG CSRGRGHGCC TRELGTEEPT VQPASKRRLL
MGTRSRAQGR RPQLPLANDL MTNLSL
//
