ID H2RFT7_PANTR Unreviewed; 216 AA.
AC H2RFT7; A0A2J8PKA0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=maleylacetoacetate isomerase {ECO:0000256|ARBA:ARBA00013199};
DE EC=5.2.1.2 {ECO:0000256|ARBA:ARBA00013199};
GN Name=GSTZ1 {ECO:0000313|EMBL:JAA03226.1,
GN ECO:0000313|Ensembl:ENSPTRP00000060382.1,
GN ECO:0000313|VGNC:VGNC:12663};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000060382.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000060382.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA03226.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA03226.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA37772.1}, Skin {ECO:0000313|EMBL:JAA22769.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA20827.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000060382.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-maleylacetoacetate = 4-fumarylacetoacetate;
CC Xref=Rhea:RHEA:14817, ChEBI:CHEBI:17105, ChEBI:CHEBI:18034;
CC EC=5.2.1.2; Evidence={ECO:0000256|ARBA:ARBA00001622};
CC -!- COFACTOR:
CC Name=glutathione; Xref=ChEBI:CHEBI:57925;
CC Evidence={ECO:0000256|ARBA:ARBA00001955};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 5/6.
CC {ECO:0000256|ARBA:ARBA00004671}.
CC -!- SIMILARITY: Belongs to the GST superfamily. Zeta family.
CC {ECO:0000256|ARBA:ARBA00010007}.
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DR EMBL; AACZ04008402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01008112; JAA03226.1; -; mRNA.
DR EMBL; GABF01001318; JAA20827.1; -; mRNA.
DR EMBL; GABD01010331; JAA22769.1; -; mRNA.
DR EMBL; GABE01006967; JAA37772.1; -; mRNA.
DR RefSeq; XP_016781982.1; XM_016926493.1.
DR PaxDb; 9598-ENSPTRP00000060382; -.
DR Ensembl; ENSPTRT00000073434.2; ENSPTRP00000060382.1; ENSPTRG00000038857.2.
DR GeneID; 453068; -.
DR CTD; 2954; -.
DR VGNC; VGNC:12663; GSTZ1.
DR eggNOG; KOG0868; Eukaryota.
DR GeneTree; ENSGT00390000006580; -.
DR HOGENOM; CLU_011226_20_1_1; -.
DR OrthoDB; 986565at2759; -.
DR TreeFam; TF105324; -.
DR UniPathway; UPA00139; UER00340.
DR Proteomes; UP000002277; Chromosome 14.
DR Bgee; ENSPTRG00000038857; Expressed in liver and 21 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016034; F:maleylacetoacetate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR CDD; cd03191; GST_C_Zeta; 1.
DR CDD; cd03042; GST_N_Zeta; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR005955; GST_Zeta.
DR InterPro; IPR034330; GST_Zeta_C.
DR InterPro; IPR034333; GST_Zeta_N.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR NCBIfam; TIGR01262; maiA; 1.
DR PANTHER; PTHR42673; MALEYLACETOACETATE ISOMERASE; 1.
DR PANTHER; PTHR42673:SF4; MALEYLACETOACETATE ISOMERASE; 1.
DR Pfam; PF14497; GST_C_3; 1.
DR Pfam; PF13409; GST_N_2; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG00358; Main_(cytGST); 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 2: Evidence at transcript level;
KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transferase {ECO:0000313|EMBL:JAA03226.1};
KW Tyrosine catabolism {ECO:0000256|ARBA:ARBA00022878}.
FT DOMAIN 4..87
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 92..212
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
SQ SEQUENCE 216 AA; 24137 MW; C1EC77596D56320C CRC64;
MQAGKPILYS YFRSSCSWRV RIALALKGID YETVPINLIK DGGQQFSKDF QALNPMKQVP
ALKIDGITIH QSLAIIEYLE ETRPTPRLLP QDPKKRASVR MISDLIAGGI QPLQNLSVLK
QVREEMQLTW AQNAITSGFN ALEQILQSTA GIYCVGDEVT MADLCLVPQV ANAERFKVDL
TPYPTISSIN KRLLVLEAFQ VSHPCRQPDT PTELRA
//
