ID   H2RJZ7_TAKRU            Unreviewed;       729 AA.
AC   H2RJZ7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=GRAM domain containing 1Bb {ECO:0000313|Ensembl:ENSTRUP00000000460.3};
GN   Name=GRAMD1B {ECO:0000313|Ensembl:ENSTRUP00000000460.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000000460.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000000460.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000000460.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC       Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
CC       Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004167}.
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DR   AlphaFoldDB; H2RJZ7; -.
DR   STRING; 31033.ENSTRUP00000052363; -.
DR   Ensembl; ENSTRUT00000000463.3; ENSTRUP00000000460.3; ENSTRUG00000000208.3.
DR   GeneTree; ENSGT00940000156649; -.
DR   HOGENOM; CLU_015189_1_0_1; -.
DR   Proteomes; UP000005226; Chromosome 11.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044232; C:organelle membrane contact site; IEA:UniProt.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR031968; VASt.
DR   PANTHER; PTHR23319:SF3; PROTEIN ASTER-B; 1.
DR   PANTHER; PTHR23319; UNCHARACTERIZED; 1.
DR   Pfam; PF02893; GRAM; 1.
DR   Pfam; PF16016; VASt; 1.
DR   SMART; SM00568; GRAM; 1.
DR   PROSITE; PS51778; VAST; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        618..638
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          365..536
FT                   /note="VASt"
FT                   /evidence="ECO:0000259|PROSITE:PS51778"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          223..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          317..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   729 AA;  83940 MW;  A876993E741951DF CRC64;
     RYVNTASNSN KSTPTCSPVL RKRSRSPTPQ SQEGETMVEK GSDHSSDKSP STPEQVVQRT
     YSLQSARSGG KNSKVSVLSP TYKQRNEDFR KLFKQLPDTE RLIVDYSCAL QRDILLQGRL
     YLSENWICFY SNIFRWETLL TVRLKDICSM TKEKTARLIP NAIQVSTDTE KHFFTSFGAR
     DRTYMMMFRL WQNALLDKPL CPKELWHFVH QCYGNELGLT SDDEDYVPPD DDFNTMGFSE
     EIPNEENEIN NDNLSKSSAE AKPEGSPPLL HKKAIPNSTL PIPANHDAPI PFDLPTEEFA
     DFLPDGELLT VPLVVEEKSS DNSGPGGPVP SPSLDFNDNE DIPTELSDSS ETHDEGEAAF
     HEDLNGRLHI NEVFKFSVDK LYDILFTQSQ FMSDFNVQRR ISDVVYQPWK KEDAGDQTRE
     IMYTISLTNP LAPKTSTASE IQTLYKVSQE SECYIIDAEV ITHDVPYHDY FYALNHYILT
     RVAKNKCRLR VSTELRYRKQ PWGLVKGFIE RNFWSGIEDN FRHLEMSLTK LEEILTESRQ
     LSPKAKGVKN STVRRKKRPL PHIRSQHLDE ALSPVTTPTD EEVIQRIKQV AGSTQTRHQS
     PEHHHLPGGF AFYSVSKLLL IISFVLVLLV FLNMMLFYKL WMLEYSAQSL TTWQGLRLHE
     SKLPQTQMEW AQLLEAQQRY HDAELQKWRE IIKSSVVLLD QMKDSLLNLQ RGIGSREYST
     ESEEKSRYH
//