ID H2RK30_TAKRU Unreviewed; 693 AA.
AC H2RK30;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=glutamine--fructose-6-phosphate transaminase (isomerizing) {ECO:0000256|ARBA:ARBA00012916};
DE EC=2.6.1.16 {ECO:0000256|ARBA:ARBA00012916};
GN Name=LOC101078323 {ECO:0000313|Ensembl:ENSTRUP00000000493.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000000493.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000000493.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000000493.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-
CC phosphate + L-glutamate; Xref=Rhea:RHEA:13237, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:58359, ChEBI:CHEBI:58725, ChEBI:CHEBI:61527; EC=2.6.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001031};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-
CC glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-
CC fructose 6-phosphate: step 1/1. {ECO:0000256|ARBA:ARBA00004775}.
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DR AlphaFoldDB; H2RK30; -.
DR STRING; 31033.ENSTRUP00000000493; -.
DR Ensembl; ENSTRUT00000000496.3; ENSTRUP00000000493.3; ENSTRUG00000000225.3.
DR GeneTree; ENSGT00940000156413; -.
DR InParanoid; H2RK30; -.
DR OMA; NDMPVVT; -.
DR UniPathway; UPA00113; UER00528.
DR Proteomes; UP000005226; Chromosome 14.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00714; GFAT; 1.
DR CDD; cd05008; SIS_GlmS_GlmD_1; 1.
DR CDD; cd05009; SIS_GlmS_GlmD_2; 1.
DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR InterPro; IPR017932; GATase_2_dom.
DR InterPro; IPR005855; GFAT.
DR InterPro; IPR047084; GFAT_N.
DR InterPro; IPR035466; GlmS/AgaS_SIS.
DR InterPro; IPR035490; GlmS/FrlB_SIS.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR NCBIfam; TIGR01135; glmS; 1.
DR PANTHER; PTHR10937; GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING; 1.
DR PANTHER; PTHR10937:SF10; GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] 2; 1.
DR Pfam; PF13522; GATase_6; 1.
DR Pfam; PF01380; SIS; 2.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51278; GATASE_TYPE_2; 1.
DR PROSITE; PS51464; SIS; 2.
PE 4: Predicted;
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 3..299
FT /note="Glutamine amidotransferase type-2"
FT /evidence="ECO:0000259|PROSITE:PS51278"
FT DOMAIN 371..510
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
FT DOMAIN 542..683
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
FT REGION 236..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 693 AA; 77581 MW; E286930E25B71F54 CRC64;
MCARIFAYLN YRVPRTRKEI FETLVKGLQR LEYRGYDSAG IAVDGPNKSD SDIHGKSISL
IKKSGKVKAL DEELYKKDSL DLDEELFTHF GIAHTRWATH GEPSIANSHP HRSDKDNAFV
VIHNGIITNY KELREYLITK GYEFESETDT EVIPKLIKYV YDNREGESVT FSTLVEQVIQ
QLEGAFALVF KSRHFPEEAV ATRRGSPLLI GVRSKEELLT DNIQVQYNGG ESCSSGSHFK
DGIQGKNTHN RPDSSTAINS VSDGKSVEYY FASDASAIIE HTNKVLYMED DDIAVVTNGN
LSIHRVNRQA GEDPVRAIQT LQMELQQIMK GNFDSFMQKE IFEQPETVVN TMRGRICFDS
NKVILGGLKD HLKEIKRCKR LMMIGCGTSF HAAVATRQVL EELTELPVMV ELASDFLDRN
TPVFRDDVCF FISQSGETAD TLMALRYCKK NGALTVGITN TVGSSICRQT NCGVHVNAGP
EIGVASTKAY TSQFVALVMF ALMMSEDKLS LQPRRLEIIN GFRVLPELIK KVLSLDDKIK
AIANELYQQK SLLVMGRGFH YATCLEGALK IKEITYMHSE GILAGELKHG PLALVDKEMP
VIMIIMRDAC YNKCQNALQQ VTARSGRPII LCCQDDPEMS QIAYQTIELP QTVDCLQGIL
SVIPLQLLSF HLAVLRGYDV DFPRNLAKSV TVE
//
