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Database: UniProt
Entry: H2RLK2_TAKRU
LinkDB: H2RLK2_TAKRU
Original site: H2RLK2_TAKRU 
ID   H2RLK2_TAKRU            Unreviewed;      1666 AA.
AC   H2RLK2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 42.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000001015, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000001015}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000001015}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   Ensembl; ENSTRUT00000001018; ENSTRUP00000001015; ENSTRUG00000000432.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028817; Na_channel_a4suB.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF186; PTHR10037:SF186; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    131    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    158    177       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    197    217       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    229    246       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    252    272       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    381    408       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    540    566       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    578    601       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    613    637       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    658    686       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    748    771       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    992   1010       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1030   1049       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1069   1095       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1194   1218       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1278   1296       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1308   1330       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1342   1361       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1405   1431       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1443   1462       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1495   1521       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      130    414       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      549    776       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      784    946       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      952   1226       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1277   1531       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       22     42       {ECO:0000256|SAM:Coils}.
FT   COILED      405    450       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1666 AA;  190365 MW;  9754558618A7D5B3 CRC64;
     EMRTLLPPVG SEVFRRFTQS SLNEIQQKQQ IREEERKRTN AQVSEELPEP ASDLEAGKPL
     PFIYGEPPHE LLNVPLEDID PFYQSQKTFI VLSKGNIIYR FNAESSLYLL SPFNALRIVA
     IKILIHSCKT LFSLFIMATI LTNCAFMTLS DPPAWSKIYR YVFTFIYTFE ATIKILSRGF
     CVGKFTFLKD PWNWLDFMVI SMAYLTELVD LGNVSVLRTF RVLRALKTIT VIPGLKTIVG
     ALIQSVRKLA DAMVLTVFCL SVFALIGLQL FMGNLRQKCV LIPQWLYESK HLEFEFERHI
     NNPDNYYYLT GQGDPLLCGN SSDAGVCPES YVCLKVGANP NYGYTSYDSF GWAFLALFRL
     MTQDFWENLF QLTLRTAGKT YMIFFVVVIF LGSFYLINLI LAVVAMAYAE QNEATLAEAK
     EKEEEYIHIL EALKKREEEV RADRSSLASQ GERVCPESCL KVSYLSWGKT RNGNFLLSCR
     DEGIVPAGHH RKTCPAISHI NESTSFEDDH RLCPPCWYAF ANIFLKWDCC GCWRHLKECL
     YAIVMDPFVD LGITICIILN TVFMAMEHYP MSADFEELLS VGNLVFTGIF TGEMVFKILA
     MDPYFYFQVG WNIFDSIIVT ISLVELGLAN VQGLSVLRSF RLMRVFKLAK SWPTLNMLIK
     IIGNSVGALG NLTLVLAIIV FIFAVVGMQL FGKNYKDCVC RISEDCVLPR WHMNDFFHAF
     LIIFRVLCGE WIESMWDCME VSGQTMCLIV FMMVLVIGNL VVLNLFLALL LSSFSGDNLT
     TQDDEGENNL QIAINRINRA MSWTKTYILL YVYTLTESNL NQHFAVSDDE EQRRVKDILA
     LTSVSSDKLV SHHCGNDFFR VPIAEAESDS DDSDYDEDKD SQCDESSVCS SVQKPEVQEE
     EMDENCVAKT PTDCWTKKCY SRCPFLDIDT SQGRGKIWCN IRRTCFSIVE NNYFESFIVF
     MILLSSGALA FEDIYLEKHQ LIKSILEYAD KVFTYVFVME MVLKWFAYGF KSYFSNAWCW
     LDFLIVDVSL VSLTANILGY SELGAIKSLR TLRALRPLRA LSRFEGMRVV VNALVGAVPS
     IFNVLLVCLI FWLIFSIMGV NLFAGKFSYC FNETSQEIID TKVVDNKTEC IALIKANFTE
     VRWKNVKVNY DNVGIGYLSL LQVATFKGWT DIMYAAVDSR DVESQPIYEV NLYMYLYFVI
     FIIFGSFFTL NLFIGVIIDN FNQQKAKLGG QDIFMTEEQK KYYNAMKKLG SKKPQKPVPR
     PEQNPFQGLV FDLVTKQIFD VFIMVLICLN MVTMMVETDE QSDKKEEVLY WINVVFILIF
     TTECTLKIIA LRRHYFSIGW NIFDFVVVIL SILGLLLADI IEKYFVSPTL FRVIRLARIG
     RVLRLIRGAK GIRTLLFALM MSLPALFNIG LLLFLIMFIF SIFGMSNFAY VKKEALIDDM
     FNFETFGNSM ICLFMITTSA GWDGLLSPIM NTPPDCDPNV ENPGTTVRGN CGSPAIGIAF
     FSTYIIMSFL VVVNMFIAII LENFNVATEE SSDPLCEDDF EMFYETWEKF DPDASQFIQY
     SKLSDFCDTL KEPLRIPQPN TIKLISMDLP LVPGDRIHCM DILLALTAEV LGDSDEMDTL
     KATMEEKFMA NNPSKVSYEP ISSTLLRKEE EVAATVIQRA YRKYLL
//
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