ID H2RM44_TAKRU Unreviewed; 670 AA.
AC H2RM44;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Dynein axonemal heavy chain 3 {ECO:0008006|Google:ProtNLM};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000001207.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000001207.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000001207.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2RM44; -.
DR STRING; 31033.ENSTRUP00000001207; -.
DR Ensembl; ENSTRUT00000001212.3; ENSTRUP00000001207.3; ENSTRUG00000000508.3.
DR GeneTree; ENSGT00940000154959; -.
DR HOGENOM; CLU_000038_0_2_1; -.
DR InParanoid; H2RM44; -.
DR OMA; CETHMEQ; -.
DR Proteomes; UP000005226; Chromosome 22.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961:SF8; DYNEIN AXONEMAL HEAVY CHAIN 3; 1.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 76..191
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 226..365
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 372..666
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
SQ SEQUENCE 670 AA; 76288 MW; A973CEDD8598FD0A CRC64;
MNSIWKLFYD SGKPHEEILP DEWSKLEGMD RMVVIRCFRP DKLIPAVQDF VVANKGQAYI
EPPNFDLAGT YNDSNCCSPL IFVLSPGTDP TAGLLKFADD LNMGGNKTQT ISLGQGQGPI
ASDMIDKAIR KGTWVVLQNC HLATSWMPAL ERICEETIVP GNTHRSFRLW LTSYPSPHFP
VSILQNGLKM TNEPPKGLRA NLLSSYVSHP ISDPDFFECC TKPVYWQKFL FGLSFFHALV
QERRNFGPLG WNIPYEFNES DLKISMRQIQ MFLDDYDEVQ LEALTYLTGE CNYGGRVTDD
KDRRLLMSLL SIFYSRDLVE KDCYELCEGG LYYVPAHSPH QEYVKYLRKL PICADPCVFG
LHSNADITKD NQETNQLLNG VLLTLPRQTS GGGKSPQQVV EELAEDILSK LPQNFDLQEV
VEKYPVKYEE SMNTVLRQEI IRFNRLIIVV RVSMVNICKA LRGQIVMSSE LEDVYNSMLV
GKIPTIWAAK SYPSLKPFGS YVADLFARLD FLQKWIDNDA PTTFWISGFY FPQSFLTGVA
QNFARKYQIP IDFLGFEYEA MDEKPEDGAY VTGLFIEGAR WDRENMVIGE SLPKILFDPL
PIMKLKPGEM AQFKHEDIYV CPVYKTSARR GTLSTTGHST NYVMSIELPS DKPQKHWINR
GVACLCQLDD
//
