ID   H2RMZ4_TAKRU            Unreviewed;       340 AA.
AC   H2RMZ4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=GDNF family receptor alpha 2a {ECO:0000313|Ensembl:ENSTRUP00000001507.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000001507.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000001507.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000001507.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GDNFR family.
CC       {ECO:0000256|ARBA:ARBA00005961}.
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DR   AlphaFoldDB; H2RMZ4; -.
DR   Ensembl; ENSTRUT00000001515.3; ENSTRUP00000001507.3; ENSTRUG00000000629.3.
DR   eggNOG; ENOG502QS3P; Eukaryota.
DR   GeneTree; ENSGT00940000156168; -.
DR   TreeFam; TF331647; -.
DR   Proteomes; UP000005226; Chromosome 21.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR   InterPro; IPR016017; GDNF/GAS1.
DR   InterPro; IPR037193; GDNF_alpha.
DR   InterPro; IPR003438; GDNF_rcpt.
DR   PANTHER; PTHR10269:SF4; GDNF FAMILY RECEPTOR ALPHA-2; 1.
DR   PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR   Pfam; PF02351; GDNF; 3.
DR   SMART; SM00907; GDNF; 3.
DR   SUPFAM; SSF110035; GDNF receptor-like; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          39..117
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   DOMAIN          118..194
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   DOMAIN          204..301
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
SQ   SEQUENCE   340 AA;  38398 MW;  0838CB0BC424B78F CRC64;
     LSSPSRLSPV PPQMRGTFPG WVPHLCLSGP GAHSEWVDCI QASEMCNQNP NCSSRYRVMR
     QCLVGKEKDA MLDNNRECQA ALEVLLGSPL YDCRCKRGMK KELQCLQNYW TIHMGLGDAC
     NLNGSCKRQR STFIGICIKE DPNRGETCSR KRCHKALRSF LDRVPPEFSH RLLFCPCQTE
     GCAERRRQTI VPDCSYNDKD KPNCLELRTL CRQDSLCRSR LADYTENCRV SAHTTSTCPN
     QDNHQACLSS YARLIGTDMT PNYVDNSFSN WTISPWCTCE GSGNQEEECY NFLRFFTENT
     CLSESPLSIG VLLTAFPFNG LLDGENNGIC LGSPYCKLHF
//