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Database: UniProt
Entry: H2RNR6_TAKRU
LinkDB: H2RNR6_TAKRU
Original site: H2RNR6_TAKRU 
ID   H2RNR6_TAKRU            Unreviewed;      1771 AA.
AC   H2RNR6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 39.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1F {ECO:0000313|Ensembl:ENSTRUP00000001779};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000001779, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000001779}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000001779}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in
CC       opposite effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   Ensembl; ENSTRUT00000001787; ENSTRUP00000001779; ENSTRUG00000000739.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17   1771       Voltage-dependent L-type calcium channel
FT                                subunit alpha. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003571693.
FT   TRANSMEM     40     59       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     71     88       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    146    169       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    225    246       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    258    280       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    404    422       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    442    469       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    528    548       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    607    631       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    716    734       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    746    769       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    789    812       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    833    866       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    957    984       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1036   1056       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1068   1087       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1164   1187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1255   1278       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1419   1453       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED     1441   1461       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1771 AA;  199845 MW;  7321AA1521F6D519 CRC64;
     PFDIFILLAI FANCVAMGVT KPFPDDDSNA TNHKLEQVEY VFLVIFTIET FTKILAYGLV
     MHPSAYIRSG WNLLDFVIVI VGLFSVIAEG MTDHKPGEAH HAAGKPGGLD VKALRAFRVL
     RPLRLVSGVP SLQIVLNSIM KAMVPLLHIG MLVMFVIIIY AIIGLELFIG RMHKTCYSST
     TGLMMEDDAS PCAFAGSGRF CVENGTECRG KWEGPNGGIT NFDNIFFAML TVFQCITMEG
     WTDVLYWMND AIGFEIPWIY FVSLVIFGSF FIINLVLGVL SGEFSKEREK AVARGELQKA
     QESKQMEEDM IGYMDWLIEA EDVDEEGNKR AAIAKKKMMK KFGWYKHSED GGESDSDDDI
     AYLDDDSGFC ASLMAKMMAN SFCDQLCQIN HTMRKNSRVA VKTTNFYWLV LLLVFLNTVA
     SASEHYGQPK WLTEMQERAN KVLLLLFTLE MLMKMYAFGL QIYFMALFNR FDCFVVCGGI
     LEMLLVEMEV IPPIGIAVLR CIRLLRIFKM TRHWAALSDL VNSLLNSMKA ICSLLLLLFL
     FLIIFALLGM QLFGGKFNFD ETQMKRSTFD SFPQALLTCF QILTGEDWNA VMYDGIMAYG
     GPIFPNMVVC IYFVILFVCD ILLNVFLAIA VDNLAGGGGK NKVEEKKEDE EEWDDDEEKE
     DEDAANEDDD WQENEEPDFS GPKEKIVPIP DGSSFFILGK KNCLRVACHN LIHHPYFTNF
     ILIFIILSSI SLAAEDPIKS HSFRNIVLGY ADYVFTSVFT VEIVLKMTVY GAFLHTGSFC
     RNAFNLLDLL VVGVSLTSFF LHSSAISVVK ILRVLRVLRP LRAINRAKGL KNVVQCVFVA
     IRTIGNILIV TTLLQFMFAC IGVQLFKGRF YSCTDEAKQT PEECKGTFVI YKDGDINHPM
     VRERVWENSD FNFDNVLNGM LALFTVSTFE GWPQLLYRAV DANAINRGPI YNYRVEISIF
     FIIYIIIIAF FMMNIFVGFV IITFREQGEA EFKNCELNKN QRQCVYYALK AQPIKIYIPK
     NQSQLKFWKI INSSQFEYIM FVLILGNTLT LAIQHYEQSK LFTSIMDILN MIFTVVFTVE
     MVIKLLALRA HHYFIDPWNS FDALIVVGSV LDIAVSEFSG SKGESGKVSI TFFRLFRVLR
     LVKLLSKGEG IRTLLWTFVK SLQALPYVGL LIAMIFFIYA VIGMQMFGKV AVDDNTNINR
     NCNFQTFFMA VLVLFRCATG EQWQEIMLGA LPGRRCDPES DIEPGEEYTC GSNLAYLYFI
     SFFMLCAYLI INLFIAVIMD NFEYLTRDWT VLGTHHLDEF KRVWSDYDPE ATGRIKHIDV
     VTMLRRIQPP LGFGKLCPHR VACKRLVDMN VPLHPDGTVT FNATLFALVR TSLKIKTEGS
     PTPTRPIDQQ NEELKIIIKK LWKRTKPKLI DEVIPPPRGD EVTCGKFYAS FLIQDYFKKF
     RKRKERERKS KRKDKAAALQ QGLRSLQDLA PEMRLAINGY NDSNVNGGSV ATSPTPYDTN
     GYNGNGYNRN GYNGYSENGS LFSTNTNGNA CNENGSGYAD SKNVRRRLLP AIPKGRRPAF
     NFQCLKPQRS LDEQTPIPGT YHGNSSPSRS RLQNQHSLDS RPSSVSSMSS ASWANTGAAG
     CTPLPGITHP SGRRGKLIYT PMMLVDEATG TRQPLWTDGT TSLPAGNRPG WYPTQARTFN
     SMRIPPVNQG YVSKGGADGL VESILISEGL GVFARDPKFV SFAKREIAEA CHMSMDEMES
     AATDLIARGA TRSISRFEDE LADEMNCVVS Y
//
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