ID H2RNW8_TAKRU Unreviewed; 518 AA.
AC H2RNW8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Polypyrimidine tract binding protein 1a {ECO:0000313|Ensembl:ENSTRUP00000001831.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000001831.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000001831.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000001831.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2RNW8; -.
DR Ensembl; ENSTRUT00000001839.3; ENSTRUP00000001831.3; ENSTRUG00000011360.3.
DR GeneTree; ENSGT01050000244924; -.
DR HOGENOM; CLU_015171_7_1_1; -.
DR Proteomes; UP000005226; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR CDD; cd12693; RRM2_PTBP1_like; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR006536; HnRNP-L/PTB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021790; PTBP1-like_RRM2.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01649; hnRNP-L_PTB; 1.
DR PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR PANTHER; PTHR15592:SF19; POLYPYRIMIDINE TRACT-BINDING PROTEIN 1; 1.
DR Pfam; PF13893; RRM_5; 2.
DR Pfam; PF11835; RRM_8; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 4.
DR PROSITE; PS50102; RRM; 4.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 41..115
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 165..241
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 324..398
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 441..516
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
SQ SEQUENCE 518 AA; 56798 MW; AEDD0EE687B7CCA8 CRC64;
MVAQSSFGYQ VTSCSVTQWL TNGNDTKKFK GDVRSSGVPS RVVHVRKLPN DINEAEVIGL
GLPFGKVTNL LMLKGKNQAF LELNSEECAQ TMVNYYSSVT PYIRNHPIYM QYSTHKELKT
DNSPNQRAQA ALQAVNALHG GGMGGMAIPT DPASIAGAAA QSPVLRVIVE NLFYPVTLEV
LHQIFSKFGT VLKIITFTKN NQFQALIQHV DSMTAQHAKL SLDGQNIYNA CCTLRISFSK
LTSLNVKYNN DKSRDYTRPD LPTADSQPSL DPQTMAAAFA APGIISASPY GGAHAFPPAF
AIQQTAAAAT RLGFTGLTPT AGHNVLLVSN LNPQSVTPHC LFILFGVYGD VMRVKILFNK
KENALVQMSD GTQAQLAMSH LNGQRLHGRE MRVTFSKHTT VQLPREGHED QGLTKDYSNS
PLHRFKKPGS KNYSNIFPPS ATLHLSNIPP AVVEDDLKRL FASSGATVKA FKFFQKDHKM
ALIQMGSVEE AIDCLIKFHN HDLGENHHLR VSFSKSTI
//
