ID H2RPF5_TAKRU Unreviewed; 1148 AA.
AC H2RPF5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Laminin subunit gamma-2-like {ECO:0000313|Ensembl:ENSTRUP00000002018.3};
GN Name=LOC101079112 {ECO:0000313|Ensembl:ENSTRUP00000002018.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000002018.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000002018.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000002018.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
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DR AlphaFoldDB; H2RPF5; -.
DR STRING; 31033.ENSTRUP00000002018; -.
DR Ensembl; ENSTRUT00000002027.3; ENSTRUP00000002018.3; ENSTRUG00000000841.3.
DR eggNOG; KOG1836; Eukaryota.
DR GeneTree; ENSGT00940000160470; -.
DR HOGENOM; CLU_002471_0_0_1; -.
DR InParanoid; H2RPF5; -.
DR OMA; ARWVQTC; -.
DR OrthoDB; 90222at2759; -.
DR Proteomes; UP000005226; Chromosome 22.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00055; EGF_Lam; 5.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF313; LAMININ SUBUNIT GAMMA-2; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 6.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00180; EGF_Lam; 5.
DR SMART; SM00281; LamB; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR PROSITE; PS01248; EGF_LAM_1; 3.
DR PROSITE; PS51115; LAMININ_IVA; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Secreted {ECO:0000256|ARBA:ARBA00022869}.
FT DOMAIN 187..357
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT COILED 610..647
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 673..700
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 770..825
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 904..931
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1148 AA; 125654 MW; 2CCACA8D247985B0 CRC64;
MLRPAAVDEL KVGNQEFEGN LNMKISSCVS LYLLLAAACV VQATYRHYSR WHCSCNGRSQ
YCLQDAWGLH CINCQGNTTG RHCERCKDGF YQQVAGLGCS ACGCDPVGAI NSTCDSRGRC
YCKEAVSGEK CTRCSDGPIG PNGCRQRRQL RGDSGSSALP CFCFGHSSRC SAQSGYSIHP
ISSTFTDGPD GWKATVDNDM GPNDALFRWS PRHQDLEVIS TNSLPVYLNA PAPYLGNQLL
SYGQNFSFSL RLDHSVRQPS QSDVVLEGSG LRVAASLGAL RSAAPCRQKV NYSFRLDEQP
SSGWRPQLST FQFQMLLQNL TTLKIRATFG QGRGYVDNVQ MVSAQRGEGR VAHWVWTCRC
PLGYEGDLCN SCSAGFKRTN PAEGAFSSCE PCGCRGGSCD PHTGDCYAAD ETPGEQTCPR
GFYRNRWHPD TCLKCPCPDG VSCTVKDGSV QPHCDQCPPG STGPRCDVCQ EGFYGDPVGA
VSGVQRACRP CECNGHISIS APGSCDGRTG ECLKCVNNTR GRSCQACLPD FYHSRASDAC
RSCDCDLQGS QSTQCDDLGR CRCKPGFQGN KCQTSNCPAC FSSIKMKMKE YATKLEEILF
LDGGGDQQSR AEMEAGLRNI KHLLDSLQRD TEELTGLERE LQEHLSSTNT TQMANRQHVH
SIAMRENNIQ RQRQSYTRNM EKVLNLLEEI KGKLDQAKDD LGSADIPAGD ASQGSQFPAL
LQAAAGLADM HQREADVVQQ RSGDALDTSL KTLALSKTLT ANENKVKELI GHLKNTYEQT
AAQVKGLENR AERLSSEAAD ENMVANNMHK EITQLEQEIP SALKDGVHSM ASVLSDLTGA
ANKGQEDFDV FQRGVEQNKV AAENLLNEGR TSGKQVEKLL NRTDVARDET NDALRRINGS
TDELRDALNT LKGFTQQINN YRTEANAAIQ RLHGINSTIQ QAVRSNEETQ SVLRDMSEDY
NQSLGTINVL ENLVNSIEGT FGSLPPQNVI VSESSQLKGD SEDLKVKLER VDGDLNIELD
AVRRLEDESV QGSAGAAGAL QQARQSRAAV DETLREINNL FSQLNQTDAV DLKRLQQVEA
SVDGAQRNVE QHLKPWLSDV EAQEAAQKRR LYGINTDIDN ILADIENLKV ILQSVPNGCF
NTLPIENP
//
