ID   H2RPX4_TAKRU            Unreviewed;       110 AA.
AC   H2RPX4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=ER membrane protein complex subunit 6 {ECO:0000256|ARBA:ARBA00020827};
DE   AltName: Full=Transmembrane protein 93 {ECO:0000256|ARBA:ARBA00031072};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000002188.1, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000002188.1, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000002188.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC       {ECO:0000256|ARBA:ARBA00011276}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the EMC6 family.
CC       {ECO:0000256|ARBA:ARBA00009436}.
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DR   AlphaFoldDB; H2RPX4; -.
DR   STRING; 31033.ENSTRUP00000002188; -.
DR   Ensembl; ENSTRUT00000002197.3; ENSTRUP00000002188.1; ENSTRUG00000000920.3.
DR   eggNOG; KOG4455; Eukaryota.
DR   GeneTree; ENSGT00390000003917; -.
DR   HOGENOM; CLU_110781_3_0_1; -.
DR   InParanoid; H2RPX4; -.
DR   OMA; MKANFEW; -.
DR   TreeFam; TF332611; -.
DR   Proteomes; UP000005226; Chromosome 15.
DR   GO; GO:0072546; C:EMC complex; IEA:InterPro.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   InterPro; IPR008504; Emc6.
DR   InterPro; IPR029008; EMC6-like.
DR   PANTHER; PTHR20994:SF0; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6; 1.
DR   PANTHER; PTHR20994; UNCHARACTERIZED; 1.
DR   Pfam; PF07019; EMC6; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        52..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        83..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   110 AA;  12118 MW;  B69D3EC39C5F7ECD CRC64;
     MAGVVAKREG PQFISEVAVR GNAAVLDYCR TSVSALSGAT AGILGLTGLF GFIFYFMSAF
     LLSVLLILKA GRRWNKFFKS RRLLFTGGLV GGLFTYVLFW TFLYGMVHVY
//