ID H2RSM8_TAKRU Unreviewed; 730 AA.
AC H2RSM8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=procollagen-proline 3-dioxygenase {ECO:0000256|ARBA:ARBA00012262};
DE EC=1.14.11.7 {ECO:0000256|ARBA:ARBA00012262};
GN Name=P3H1 {ECO:0000313|Ensembl:ENSTRUP00000003144.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000003144.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000003144.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000003144.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|ARBA:ARBA00001962};
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
CC -!- SIMILARITY: Belongs to the leprecan family.
CC {ECO:0000256|ARBA:ARBA00006487}.
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DR AlphaFoldDB; H2RSM8; -.
DR Ensembl; ENSTRUT00000003162.3; ENSTRUP00000003144.3; ENSTRUG00000001367.3.
DR GeneTree; ENSGT00940000158725; -.
DR InParanoid; H2RSM8; -.
DR OMA; HTPSEMF; -.
DR Proteomes; UP000005226; Chromosome 19.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR GO; GO:0019797; F:procollagen-proline 3-dioxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0032963; P:collagen metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR039575; P3H.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR14049; LEPRECAN 1; 1.
DR PANTHER; PTHR14049:SF5; PROLYL 3-HYDROXYLASE 1; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR SMART; SM00702; P4Hc; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 550..664
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 730 AA; 83164 MW; AE451C6105C8B615 CRC64;
MELRNPLIFC FCFIFPPCFS DLSSHFVLEP YDFLFDSAVE AYYKGDWLSV ILNMEKALRN
KATVRKVKTQ CRLGCANQTA FGDQLAGTGD PVPGSGSLAD LGFFQKILRR ADCVKTCESE
KLGSPTLHEV TEDVELEFRK RTPYNYLQVA YFKINKLDKA VAAAHTFFQA NPDHVEMRQN
LDYYKMMAGV EEGHFKDLEA REHMAEFLLG KRFYSNDSFE QAAEHFEVAV REFFTSNQEC
RVLCEGAYNY DGYNYMEYSA DLFQTITDHY MQVLSCKQRC ALELATNTDQ PFDDFLPSHF
NYLQFSYYNS ENLEQAIECA KTFLLFYPDD EVMKDNLAYY SVMLGEDKAQ TISPRQQSML
EKELLYFGYE AFGITFVDPV VKRFVFSVRL RADRETAARI TEEIGNLMKE IETLVEEKKK
DSSDVAKMVA PQPGVPQVQE DDIRVSMTDK QLNGSQRVLL DKVISEDECR ELQRLSNAAA
LKGDGYRGTP SPHSPGEMFQ GVTVLKALKL GQEGKVPLKS ARAFFDVSEK ARRILELYFQ
LKTPLYFSYS HLVCRSAIDE KQEARTDLSH PVHADNCLLV SEMNECIKEP PAYTHRDYSA
ILYLNDDFEG GDFIFTKLDA KTVTAEIRPQ CGRMVGFGAG KENPHGVRAV TKGQRCAVAL
WFTLDPAHEE KVGMISTTPT AGSSSAAFML WLRQAALLFW TSLLLPVQER ADENLHPLLF
CRRGSKLRRC
//
