ID H2RT50_TAKRU Unreviewed; 784 AA.
AC H2RT50;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=TATA-box binding protein associated factor 4 {ECO:0000313|Ensembl:ENSTRUP00000003317.3};
GN Name=TAF4 {ECO:0000313|Ensembl:ENSTRUP00000003317.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000003317.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000003317.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000003317.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TAF4 family.
CC {ECO:0000256|ARBA:ARBA00006178}.
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DR AlphaFoldDB; H2RT50; -.
DR STRING; 31033.ENSTRUP00000003317; -.
DR Ensembl; ENSTRUT00000003336.3; ENSTRUP00000003317.3; ENSTRUG00000001439.3.
DR GeneTree; ENSGT00390000011620; -.
DR HOGENOM; CLU_010576_0_0_1; -.
DR InParanoid; H2RT50; -.
DR OMA; GQTMQGG; -.
DR Proteomes; UP000005226; Chromosome 3.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd08045; TAF4; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 1.20.120.1110; TAFH/NHR1 domain; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR045144; TAF4.
DR InterPro; IPR007900; TAF4_C.
DR InterPro; IPR037249; TAFH/NHR1_dom_sf.
DR InterPro; IPR003894; TAFH_NHR1.
DR PANTHER; PTHR15138; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4; 1.
DR PANTHER; PTHR15138:SF18; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4; 1.
DR Pfam; PF05236; TAF4; 1.
DR Pfam; PF07531; TAFH; 1.
DR SMART; SM00549; TAFH; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF158553; TAFH domain-like; 1.
DR PROSITE; PS51119; TAFH; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 362..459
FT /note="TAFH"
FT /evidence="ECO:0000259|PROSITE:PS51119"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 82246 MW; 6A10980DB8052C6B CRC64;
MDDGAAGIAA AAAAAEPSVT AVQEQPKTGA AGGVITVATE AKNKSGPNGV QTVNGSAVPM
NCHLTGGASV DTGGDSAQPA ASVNNGPASG PGAAAASATS IIRTASPNNV TPAQRTVPTV
TLVRPPVPKP SSSSPASPAA CSSSGSVPDK VEGTKPIIQA VAPAATATIT SPTVLQNLRT
PAPSTIAIST GGGVRPLGQQ MVAPRLAQPQ QTTTSVQNIQ LPPGMVLVRS ESGQLLMFHQ
QTLAQMKAQS QSQSAITPRL SAPASTPPVQ VASLQAPAAS LLNRAVAPAT IIKQVSTVYT
TVAGTTTLQR PPVLQNAIML GGTVAAPGQP LGTATTVQPG ASVPQRVTGT SATPTAFTAE
TLENVKKCRS FLSTLIKLTS NGKQSSETTA NVKELIKKLL EAKIEAEDFT SRLYRELSSS
PQPYLVPFLK RSLPALRQMT PDSEAFIQQS LLPQTNTPAA AASTALAAVV LRPPLSTAAP
TSTSTSTSTA LTKATVISLS QAPHSKPTLV ILHLYLAASL SFMSPPSLRD DDDINDVASM
AGVNLTEESA NILATNSELV GTVTRSCKDE TFLSPSLLGH RALEIGKRFG VGELGADVVR
YISHAAQQRL QDLLEKVSHV AQLRSHILKE DGRHEQVSDV RAQLKFFEQL DQLERQRKEE
QEREILLKAA KSRSRQEDPE QLRLKQKAKE MQQQELAQIR HREANLTALA AIGPRKKRKT
DAPVRGASGS GWGPPPQPGG SSGSGSRQFM RQRITRVNVR DLLFCLENER GTNRSQLLYK
GFLK
//
