ID H2RUC4_TAKRU Unreviewed; 844 AA.
AC H2RUC4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Cadherin-2-like {ECO:0000313|Ensembl:ENSTRUP00000003741.3};
GN Name=LOC101065779 {ECO:0000313|Ensembl:ENSTRUP00000003741.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000003741.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000003741.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000003741.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004135}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}. Cell surface
CC {ECO:0000256|ARBA:ARBA00004241}.
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DR AlphaFoldDB; H2RUC4; -.
DR STRING; 31033.ENSTRUP00000066251; -.
DR Ensembl; ENSTRUT00000003761.3; ENSTRUP00000003741.3; ENSTRUG00000001621.3.
DR GeneTree; ENSGT00940000155981; -.
DR Proteomes; UP000005226; Chromosome 20.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 4.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF79; CADHERIN-2; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR01820; DESMOCOLLIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 654..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 100..207
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 208..322
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 332..437
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 438..544
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 543..654
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 844 AA; 93886 MW; 6BE5D4964A5C24F3 CRC64;
VTMDCSRGKV RFEVGQSADF RVSEAGEIYT SRPLSLGRDR AVEGVVYAQD LRTKQLWKTK
FFLLVKHGDA TLTQHLPEIL FPWRSMIVKG DGTVRRVKRD WVIPPINVPE NSRGQFPEDL
VRIRSDRDKN WMLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDREHI SNFHLRAHAV
DLNGNQVENP IDIVINVIDQ NDNRPEFTHT VFNGSVPEGS KPGSFVMTVT AVDKDDPKTA
NGMLRYKILS QNPQSPSSNM FTINNKTGDI ITVAAGLDRE KVTQYTLIVQ ATDMEGNPTY
GLSNTATTVI RITDVNDNPP EFTTDTFSGD VDENRVNVIV ANLTVTDKDQ PHTQAWSAVY
RIVAGDPTGR FSIPTDPTTN EGLLTVVKPI NYEEKRSFML MVEAQNEVPL ARGIHLPRQP
TVTVSVRILD VNESPEFSPN PKSIKLEEGL PAGSLLTTFT AQDPDRFMSQ NVRYSKMYDP
ANWLQIDPFN GRISTIAILD RESPYVKNNQ YNVTFMATDG DPAANGTGTL QIYLMDINDN
APHVFPPEVE MCEKPGPNAI NITASDPDLS TNAGPFAFDL VGRPLDVRRN WTLSHLNGEY
AQLRLQISSL SSGIYEVPIM ITDSGNLPMS NTSHLRVKVC QCDHHGDCVD MERIIAAGLG
TGAIIAILIG IIILLVLVLL FVMWMKRRDK ERQAKQLLID PEDDVRDNIL KYDEEGGGEE
DQDYDLSQLQ QPDTLESECM KVGIRRLDER PLHHKHQYPL RSAAPHPGDI GEFIHEGLKA
ADNDPTAPPY DSLLVFDYEG SSSTAGSLST LHSSSSCEDQ EYDYLGDWGP RFRKLADLFG
GGDD
//
