ID   H2RYJ6_TAKRU            Unreviewed;       969 AA.
AC   H2RYJ6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Patched domain containing 1 {ECO:0000313|Ensembl:ENSTRUP00000005217.3};
GN   Name=PTCHD1 {ECO:0000313|Ensembl:ENSTRUP00000005217.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005217.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000005217.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000005217.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   AlphaFoldDB; H2RYJ6; -.
DR   STRING; 31033.ENSTRUP00000005217; -.
DR   Ensembl; ENSTRUT00000005248.3; ENSTRUP00000005217.3; ENSTRUG00000002271.3.
DR   eggNOG; KOG1934; Eukaryota.
DR   GeneTree; ENSGT00940000157080; -.
DR   InParanoid; H2RYJ6; -.
DR   OMA; KAPQFAH; -.
DR   OrthoDB; 2876883at2759; -.
DR   TreeFam; TF331806; -.
DR   Proteomes; UP000005226; Chromosome 10.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796:SF36; PATCHED DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        303..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        366..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        407..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        441..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        584..603
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          325..463
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   969 AA;  107280 MW;  0194CB1AE1614EE1 CRC64;
     MLGGARGFSG RWESLEPRPR ARMLRQVLHA GLRTSFHALG RFVASHPVFF ASAPVLLSIL
     LGASFSRYRV EEDVESLLAP KHSLAKIEGN LVESLFPVNR SKHALYSDLQ TPGRYGRVII
     TARKGSVLDP VHLDTILTLH SQIYQMQVTV PTSAFNYSFS YLCLHDEKNA CIIDDIIRAM
     EEIQSARSTN GSVPVLHYPI TQLADGRQAY IGHQLGGVQG WGPGGSVHGP RAGARGEGVR
     SARALQLTYY LQARGDLMDR VASQWEKAFC AELENFAALH PKLGLYPSTS SSLKMDFQFS
     SVLARRPLLA SLGLCGVLAV LCCSMRDCVR SKPWLGLLAL LSVTLSGLTA AGILNLTGAT
     YNSTYLGIPF VMLGHGLFGS FEMLSSWRRT REDQHVKERV ASVFEDVMLR FSGSTLIHLM
     TLGLAASPLT NMEAVRLFCR TAALAVTISY IYMLSFYGSC LVFTGYLETG YRHGCFCRRV
     PKPDRLDSKP AWYRCLMYTR YQEETQNHQP PGVGHGSVPI TNLTHTHTTH HPAALGHSCP
     AANSTHPQPH SSGGDPHPQD SHLLLGCVRH CFGDWITNTY VKPFVVLLYL VYISFGLMGF
     LQVTQGSDPS ALVAMDTATV LYTRAQQRYF SSYSPVIGFY IYESAPYWND SVQQDLLEYA
     KGFQRISWLE AYLNYLSDRN QSTSQPRENF TRTLRQAFLR EPQFAHFADD IIFAERGQGE
     EPDLAASRIF LVAKTTENKR EEMSLLLDTL RRLSLTSRVR FLIFNPSFVY LDRYAAAVSS
     PLRHSLLAVL FLLGLSSLAI VEPLVSVWLG LTLLSVQFGV LGFMTLWGVE LDCMSVLCLI
     SALGHSADCS GPLLCGFASG RGDSRTRWVR VALERHGVPS LQTLLCYSVA LVPVGSVRSN
     LTHTLFRCLT LTAGCSALHT LAFLPTLLTF LPPSKTRGPR QEGEGQRQAV ECVEMNDSNT
     RVVDQITTV
//