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Database: UniProt
Entry: H2RZB8_TAKRU
LinkDB: H2RZB8_TAKRU
Original site: H2RZB8_TAKRU 
ID   H2RZB8_TAKRU            Unreviewed;      1741 AA.
AC   H2RZB8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 42.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=LOC101061091 {ECO:0000313|Ensembl:ENSTRUP00000005489};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005489, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000005489}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000005489}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   Ensembl; ENSTRUT00000005522; ENSTRUP00000005489; ENSTRUG00000002374.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    176    197       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    273    294       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    300    320       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    390    409       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    429    456       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    588    611       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    623    642       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    663    683       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    703    732       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    787    817       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1028   1046       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1067   1083       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1095   1114       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1159   1179       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1269   1292       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1351   1369       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1381   1403       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1415   1434       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1482   1504       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1572   1595       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1612   1647       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      453    487       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1741 AA;  196854 MW;  10824C16A5013EFD CRC64;
     DSESLTLAVQ NKTAADVKRI NRCKQTPPEP NIEHLGNPEV VTSLCDAKMA TILPPPGTAL
     FRHFTRQSLA TIERLKEETL IAPKAGAHEE EEPPTPNPDL EAGKSLPMIF GDPPSELLGT
     PLEDIDPFYK AQKTFVVVTK GNTIYRFNAE PACYILSPFS LVRRGAIKIL IHSYPFAQLF
     GTLIMITILS NCVFMTMSNP PAWSKTVEYV FTGIYTFEAT VKVLSRGFCV GPFTFLRDPW
     NWLDFMVISM AYITEFVDLG NVSALRTFRV LRALKTITVI PGLKTIVAAL IQSVKKMVDV
     MILTVFALAV FALVGLQLFM GNLRHKCIRW PIANTLDSNS TFDFTEYIEN AENQYFLEGS
     KDALLCGNST DAGKCPEGYL CMKAGRNPNY GYTSFDSFGW AFLALFRLMT QDNWESLFQL
     TLRAAGQTYM LFFVVVIFLG SFYLINLILA VVAMAYDEQN QASQQEAKEK EEEFQRLLEQ
     LKNQDLTGSD VADDEQSLEN NEALKDCNSA ADYELREKEE SSVHSVLHLD EPGLRERSAS
     VATAAATAME ELEEAQRPCP PIWYRFADIF LKWNCCEKWV VFKKWVHFVV MDPFVDLAIT
     ICIVLNTLFM AMEHYPMTEE FDYMLSVGNL VFTGIFAAEM FFKLIAMDPY YYFQVGWNIF
     DSIIVTLSLV ELGLANVQGL SVLRSFRLLR VFKLAKSWPT LNMLIKIIGN SVGALGNLTL
     VLAIIVFIFA VVGMQLFGKS YKDCVCKISS DCELPRWHMN DFFHSFLIVF RILCGEWIET
     MWDCMEVAGA GMCLVVFMMV MVIGNLVVLN LFLALLLSSF SGDNLSVGDD DGELNNLQIA
     IGRITRGGNW LKAFLIGTVQ RVLGREPQKP AEEDPADEGE GKTEGMEMNH LDGFKLADGI
     ANCLVGGQPS GVTLDGESSI TVPIALGESD SENPSEDDDD QEDDVDSELM GALTDGDSSV
     CSTVDYQPPE PEVQEEEEEE PDLVEPEACF TDNCVKRWPC LNVDISQGKG KKWWNLRKTC
     FTIVEHDWFE TFIIFMILLS SGALAFEDIY IERRRTVKIV LEFADKVFTF IFVIEMLLKW
     VAYGFKTYFT NAWCWLDFFI VDISLISLSA NLMGFSDLGP IKSLRTLRAL RPLRALSRFE
     GMRVVVNALI GAIPSIFNVL LVCLIFWLIF SIMGVNLFAG KFYRCINTTT AELFPISVVN
     NKSDCVALQE ATQEARWVNV KVNYDNVAKG YLSLLQIATF KGWMDIMYPA VDSREVEEQP
     SYEINLYMYI YFVIFIIFGS FFTLNLFIGV IIDNFNQQKK KLGDKDIFMT EEQKKYYEAM
     KKLGSKKPQK PIPRPANLIQ GLVFDFISQQ FFDIFIMVLI CLNMVTMMVE TDDQSPAKED
     FLFKVNVAFI VVFTGECTLK LFALRHYFFT NGWNIFDFIV VILSIAGTML SDIIEKYFVS
     PTLFRVIRLA RIGRILRLIK GARGIRTLLF ALMMSLPALF NIGLLLFLIM FIFSIFGMSN
     FAYVKKEAGI NDMFNFETFG SSIICLFQIT TSAGWDTLLL PMLNKEPPDC DPAFENPGTD
     VKGNCGNPMM GMVFFCSYII ISFLVVVNMY IAIILENFNV AQEESGDVLC EEDFEMFNET
     WEKFDTGGTQ FIEYSQLSDF CDALQEPLRV AKPNRQRLIE MDLPLVIGDR IHCVDVLLAV
     TQEVLGDTIE MVAMRESIEA KFNLNNPTSA SYAPITTTVR QKEEDMAAVV IQRAYRNHLH
     K
//
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