ID   H2RZU0_TAKRU            Unreviewed;       796 AA.
AC   H2RZU0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Phospholipase A2 activating protein {ECO:0000313|Ensembl:ENSTRUP00000005661.3};
GN   Name=plaa {ECO:0000313|Ensembl:ENSTRUP00000005661.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005661.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000005661.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000005661.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the WD repeat PLAP family.
CC       {ECO:0000256|ARBA:ARBA00008495}.
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DR   AlphaFoldDB; H2RZU0; -.
DR   STRING; 31033.ENSTRUP00000005661; -.
DR   Ensembl; ENSTRUT00000005696.3; ENSTRUP00000005661.3; ENSTRUG00000002447.3.
DR   eggNOG; KOG0301; Eukaryota.
DR   GeneTree; ENSGT00550000074944; -.
DR   HOGENOM; CLU_011791_2_0_1; -.
DR   InParanoid; H2RZU0; -.
DR   OMA; RTFDTCD; -.
DR   OrthoDB; 1116432at2759; -.
DR   TreeFam; TF105944; -.
DR   Proteomes; UP000005226; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 3.10.20.870; PFU (PLAA family ubiquitin binding), C-terminal domain; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR015155; PFU.
DR   InterPro; IPR038122; PFU_sf.
DR   InterPro; IPR013535; PUL_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR19849; PHOSPHOLIPASE A-2-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR19849:SF0; PHOSPHOLIPASE A-2-ACTIVATING PROTEIN; 1.
DR   Pfam; PF09070; PFU; 1.
DR   Pfam; PF08324; PUL; 1.
DR   Pfam; PF00400; WD40; 7.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS51394; PFU; 1.
DR   PROSITE; PS51396; PUL; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          108..138
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          147..178
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          227..258
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          366..463
FT                   /note="PFU"
FT                   /evidence="ECO:0000259|PROSITE:PS51394"
FT   DOMAIN          533..794
FT                   /note="PUL"
FT                   /evidence="ECO:0000259|PROSITE:PS51396"
FT   REGION          488..509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   796 AA;  86452 MW;  CB385613917AC2FC CRC64;
     MASSNSYKLR CSIPGHEMDV RGLASTVFPE GAFVSVSRDR TGRVWVPNSS PDGGFSEMHC
     VSGHSNFVSC VCMIAPTDKY PRGLIATGGN DNNICVFSLD QEQPLYILKG HKNTVCTLSS
     GKFGTLLSGS WDSTAKVWLN EKCMMTLEGH SAAVWAVLIL PEQGLMLSGS ADKTIKLWRA
     GHCDRTFTGH EDCVRGLAVI SSTEFFSCSN DTSVRRWLVT GECVQVYHSH TNYIYSMAVF
     PNSQDFISTG EDRSLRIWRG GECSQTIRLP AQSVWCCCIL PNGDVVVGAS DGIIRVFTEA
     EDRTASPEDL QAFEDELAKA TIDPKTGDLG DIKLEDLPGR EHLAEPGQRD GQTRLIKEGQ
     KVEAYQWSVA DDRWVKIGDV VAGSNQQTSK SVMYEGKEYD YVFTIDINEG GPSLKLPYSV
     SEDPWLTAHN FLQRNDLSPM FLDQVANFII ENTKGHVVGP SAPGVADPFT GGARYVPGAS
     DGRSGFGADP FTGSGRYIPG SGPDPSAPVG VADPFTGGGA YSSAALRHTA TNIYFPKTEA
     VTFEQANTSQ IFAKLKELNE GTPPEHRLTE ETLDTLEGLL EAVCDPSKPP PTLQQMSLLW
     KAVHWPEDIV FPVLDILRLA VRHPLVNERL CGEAEGIQLC NHLLSLMSPE GRPANQMLAL
     RTLCNCFSGR QGRALLMAHR DTVLSRAADL SAVCNKNIHI ALATVAVNYA GCLHSQPDLE
     AKAQCLSVVS KALETVQDKE AVFRLLVALG TTVAFDKTAQ DLARSLGVNS QISKYSSGSE
     PSKVAECCRL VLKELQ
//