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Database: UniProt
Entry: H2RZU7_TAKRU
LinkDB: H2RZU7_TAKRU
Original site: H2RZU7_TAKRU 
ID   H2RZU7_TAKRU            Unreviewed;      1451 AA.
AC   H2RZU7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 41.
DE   SubName: Full=Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a {ECO:0000313|Ensembl:ENSTRUP00000005668};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005668, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000005668}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000005668}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   Ensembl; ENSTRUT00000005703; ENSTRUP00000005668; ENSTRUG00000002449.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1451       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003572491.
FT   TRANSMEM    146    165       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    255    277       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    415    436       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    448    466       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    541    563       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    615    639       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    716    735       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    755    776       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    785    804       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    847    869       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    958    983       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1037   1054       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1066   1092       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1169   1187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1259   1283       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1418   1451       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      285    305       {ECO:0000256|SAM:Coils}.
FT   COILED      635    662       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1451 AA;  166613 MW;  947BFDBC9EE9C9C5 CRC64;
     PFEWMILATI IANCIVLALE QHLPDGDKTP LSERLDDTEP YFIGIFCFES GIKILALGFA
     FHKNSYLRNG WNVMDFVVVL TGKTSMYCSD GGALPGKITQ HPPWKSSDFD LRTLRAVRVL
     RPLKLVSGIP SLQVVLKSIM KAMIPLLQIG LLLFFAILMF AIIGLEFYMG KFHQTCFDNQ
     TFEIREDFPC GEFPPSRLCP EGTVCRKNWL GPNYGITQFD NIFFAILTVF QCITMEGWTE
     LLYWSNDASG SAWNWMYFIP LIIIGSFFML NLVLGVLSGE FAKERERVEN RREFLKLRRQ
     QQIERELNGY LEWICKAEEV ILADDESSRR RATKNHKSKA ELLNQEEDKH SLPLSLAISL
     SLCVSLYFKG KPQEHTDVIL SCISVLPDSP LLLSCPLRRE RRLRFLIRRV VKSQAFYWTV
     LCLVGLNTMC VAVVHYDQPE PLSDFLNFAE FVFLGIFLTE MFVKMYGLGR QAYLNSSFNC
     FDCIVICGSI FEVLWSIIQP GTSFGISVLR ALRLLRIFKV TKYWASLRNL VVSLLNSMKS
     IISLLFLLFL FIVVFALLGM QLFGGQFNFE NGTPPTNFDT FPAAIMTVFQ ILTGEDWNMV
     MYDGIKSQGG VHKGMAFSVF FIVLTLFDTL LNVFLAIAVD NLANAQELTK DEQEEEEAAI
     NKNANTEPLP AKEDMDEDDD DKAGEGGPRP MPPYTSMFIL TTTNPFRRAC HYVCTLRYFE
     MCILLVIAMS SIALAAEDPV WPDSPRNNVL RYFDYVFTGV FTFEMLIKMV DLGLVLHQGS
     YFRDLWNILD FIVVSGALVA FAFTKGKDIS TIKSLRVLRV LRPLKTIKRL PKLKAVFDCV
     VNSLKNVLNI LIVYLLFMFI FAVVAVQLFK GRFFYCTDES KEFERDCRGE YLVYDNEVKA
     QKREWKKYDF HYDNVAWALL TLFTVSTGEG WPQVLKHSVD ATYENQGPSP GYRMEMSIFY
     VVYFVVFPFF FVNIFVALII ITFQEQGDKM MEDYSLEKNE RACIDFAINA RPLTRHMPQN
     KLSFQYRMWE FVVSPPFEYT IMAMIALNTV VLMMKYDEAS KSYEAVLANL NIVFTSLFSM
     ECVLKIIAFG VLKCQNYFKD GWNIFDCVTV LGSITDILVT ELGSATKDHD NFINLSFLRL
     FRAARLIKLL RQGETIRILL WTFVQSFKAL PYVCLLIAML FFIYAIIGMQ LFGNIAIEED
     DENAINQHNN FRTFIQALML LFRSATGEAW HEIMLACLGN KECDPLSGNA DPECGSQFAY
     LYFVSFIFFC SFLMLNLFVA VIMDNFEYLT RDSSILGPHH LEEYVRIWAE YDPAACGRIH
     YKDMYSLLRV IDPPLGLGKK CPHRVACKRL LRMDLPVADD NTVHFNSTLM ALIRTALDIK
     IGGIDKHQMD AELRKEMMAI WPNLSQKHLD LLVTPHKSTD LTVGKIYAAM MIMEYYRQSK
     IKRSQALRDE Q
//
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