ID H2S2T1_TAKRU Unreviewed; 610 AA.
AC H2S2T1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=E3 ubiquitin/ISG15 ligase TRIM25 {ECO:0000313|Ensembl:ENSTRUP00000006703.3};
GN Name=LOC101076539 {ECO:0000313|Ensembl:ENSTRUP00000006703.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000006703.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000006703.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000006703.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2S2T1; -.
DR STRING; 31033.ENSTRUP00000006703; -.
DR Ensembl; ENSTRUT00000006748.3; ENSTRUP00000006703.3; ENSTRUG00000002882.3.
DR GeneTree; ENSGT00940000164979; -.
DR InParanoid; H2S2T1; -.
DR OMA; KRGVHYW; -.
DR OrthoDB; 5359093at2759; -.
DR Proteomes; UP000005226; Chromosome 17.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR CDD; cd19769; Bbox2_TRIM16-like; 1.
DR CDD; cd16597; RING-HC_TRIM25_C-IV; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 4.10.830.40; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR PANTHER; PTHR25465:SF40; E3 UBIQUITIN_ISG15 LIGASE TRIM25; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 13..53
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 420..610
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
SQ SEQUENCE 610 AA; 68137 MW; 46C166508362DE33 CRC64;
MAGLLQLEED LSCSICLSTF DCPVTVPCGH NFCNNCLLLT WADCCSFSCP QCRAVFPTRP
DLKKNTVLST IVESFSSKMA DKMEAKLSGE PTKVEKDGVI LCDTCMETEA SKTCLTCMAS
FCEEHLKPHR MNPVFSLHPL VEPVRNLFEW TCQNHHKLME FFCSQHGQVI CSLCHQQDHK
GCCVISAEEQ RNLKKAYFKD QLDFLDKKRV QNEKVIGEMS MLPESLQNSA TSTKKALAAE
YQRIRDMLTQ EEQNALLAVD HEVQNGHVKI KTLMKKFTSN ISTISKAKEH IQSVLKEPQT
LAFLQASFDL PPAAKFDPHT PRINLDSPNV KLSKDFATSL NQFLTESFKM TPEARLGRLK
IAGVAEEKST PVPPAKAAAK KNKQMKKDLS KSMENLLNMK EMLSGLHVAS ASKLGAGPQE
ALDITSVKDP HELLIYARTL TLDRTTANKR IVMSDGYTRA TVADQPLNYP NCPQRFTVCS
QVLGSTGFNT GRHYWEVLLS SNNFIGIGLT YQDIDRGGLS SRLGRNSVSW CIEWLNNKLS
AWHDTKETVL ENTHPKCVGV LLDCEGGTAT FYNVAKKATP FHSFVFHFAK AVYPAFWVFP
GGSSLSLRRL
//
