ID H2S869_TAKRU Unreviewed; 620 AA.
AC H2S869;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Exonuclease 3'-5' domain containing 2 {ECO:0000313|Ensembl:ENSTRUP00000008594.2};
GN Name=exd2 {ECO:0000313|Ensembl:ENSTRUP00000008594.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000008594.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000008594.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000008594.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2S869; -.
DR STRING; 31033.ENSTRUP00000008594; -.
DR Ensembl; ENSTRUT00000008645.3; ENSTRUP00000008594.2; ENSTRUG00000003672.3.
DR eggNOG; KOG4373; Eukaryota.
DR GeneTree; ENSGT00390000014318; -.
DR HOGENOM; CLU_019718_1_0_1; -.
DR InParanoid; H2S869; -.
DR OMA; TPKENQC; -.
DR OrthoDB; 8362at2759; -.
DR TreeFam; TF324246; -.
DR Proteomes; UP000005226; Chromosome 2.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd06141; WRN_exo; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR13620; 3-5 EXONUCLEASE; 1.
DR PANTHER; PTHR13620:SF104; EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 97..260
FT /note="3'-5' exonuclease"
FT /evidence="ECO:0000259|Pfam:PF01612"
FT REGION 291..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 69416 MW; 8A852280D70AC784 CRC64;
MSQRGPLAAV ITTVLGLTFG GVLAWRFYQT KRKRLPSFQK VADPVDALGS PPPEKEVKDC
GTQPPPAVHM PTCEQLLAVK PLTVSCEDEW QQLWPRMQKE LSLFPVLGFD CEWVSVKGRA
SSVSLLQMAT YSGLCVLVRL QAFRSCQQPL PPTLVALLRD ARLFKVGVGC YEDGKRLARD
CGLALSCTVD LRHLALRQKE AKVNNGLSLK SLAADLLNVG LDKSVELRCS DWEADELTLE
QVTYAARDAQ VSVALFLNLL GLLSEAGPAS SSGSSYPELA ARCQGLVDVP FRGRGDGDSR
GAEGERKRRL RRTPTLESPE SGDQQVPDPR RNSKRKPLGV GYSARKSPLY DNCFLHAPDG
QPLCTCDKKK ARWYLDKGIG ELQSEEPFVV RLLFEPSGRP DSQQDYYLTA KENLCVVCGK
ADSYIRKNIV PHEYRRHFPI EMKDHNSHDI LLLCTSCHAT SNVYDGFLKQ QLADEFAAPQ
GCEEGVRLME DPDRRRVRSA ARVLLSAAEA LPQRRREELQ LLIRNFLDMK EEEELTDAAL
QQAAALETQI LNEAYVPHGL KVVRAHARRG LPGLMELERR WRQHFLASMQ PRHLPPLWAV
DHNHSKFLRK YGAELPVQPS
//
