ID H2S8J0_TAKRU Unreviewed; 4549 AA.
AC H2S8J0; H2S8I6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Plectin-like {ECO:0000313|Ensembl:ENSTRUP00000008715.3};
GN Name=LOC101078378 {ECO:0000313|Ensembl:ENSTRUP00000008715.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000008715.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000008715.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000008715.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSTRUT00000008766.3; ENSTRUP00000008715.3; ENSTRUG00000003715.3.
DR GeneTree; ENSGT00940000162855; -.
DR Proteomes; UP000005226; Chromosome 7.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd06503; ATP-synt_Fo_b; 2.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 5.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 3.90.1290.10; Plakin repeat; 6.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF20; PLECTIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00681; Plectin; 14.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00250; PLEC; 33.
DR SMART; SM00150; SPEC; 5.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF75399; Plakin repeat; 7.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 85..188
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 201..306
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 825..882
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1668..1728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2036..2055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2099..2156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2537..2587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4482..4514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 781..808
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1216..1285
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1358..1452
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1482..1586
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 13..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1668..1723
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2036..2053
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2537..2559
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2568..2587
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4549 AA; 520293 MW; A49C883667A1A21E CRC64;
TPIIQQLTDS ESKEIEAMAE RKHRHGVQTP EQESSVEQIA APCPGDTLPW NLSKHQRIKR
SKSTSGEVLD PAERAVIRIA DERDRVQKKT FTKWVNKHLI KADRRVDDLY EDLRDGHNLI
SLLEVLSGEK LPREKGHMRF HKLQNVQIAL DFLKHRQVKL VNIRNDDIAD GNPKLILGLI
WTIILHFQIS DIQVNGQSED MSAKEKLLLW SQRISDGYQN IRCENFSTSW RDGKLFNAVI
HKHYPRLIDM GRVYHQTNLE NLEQAFDVAE RDLGVTRLLD PEDVDVPHPD EKSIITYVSS
LYDAMPRNAV QYGAKASELE LRWQEYYELV TFLLQWIRQH IVIFGEKKFP TSYEEIELLW
RQFLKFKETE LPVREGEKNH SKAIYQSFES AVHAGQVKVP PGYHPIDVEK EWGHLHVAML
ERERLLRIEF ERLERLQRIV SKIQMESELC DGELSRLESL LQTDIRLLNA GKPAQHAAEV
ERELDKADNI IRLFFNDVQI LKDGRHPQAD QMYRRVYRLH ERLVNLRSDY NLRLKATRTT
TQTTLTQNIQ QTTMKVRPEM DDVTLRYVQD LLAWVEENQH RIDEAQWGSD LPSVESQLGS
HRGLHHTVED FRSKIERAKA DETQLSPVSK GAYREYLGKL DLQYGRLLNS SKSRLRNLDS
LHAFVSAATK ELMWLNDKEE EEVNYDWSDR NTNMAAKKDN YSGLMRELEL REKKINDIQA
LGDKLVRDGH PGKQTVEAFT AALQTQWSWI LQLCCCIEAH LKENTAYYQV SLRIFDENIH
IKKLFNQHQE EKEQLNEFKT IVTNLNKRAK SVIQLKPRNP TTPIKGKLPV QAVCDFKQQE
ITVHKGDECA LLNNSQPFKW KVLNRSGHEA TVPSVCFLVP PINKEAVDSV SSLDAGHQQM
ISMWQTLHIN VKSLLSWQYF MKDFTQIHSW NINMLKNMKP EEYRLIMRNL ELHYQDYMRD
SQNSQLFGPD DRMQVEEDYT KATQHFDSLL HTMEKGQQDE TLCKNYISEV KDLRLRIEDC
EAGTVARIRK PVLKEPLREC VQKTSEQQKV QVELEGLKKD LNKVSVKSQE VLASPQPSAS
TPVLRSELDL TVQKMDHAYM LSSVYLDKLK TVEMVIRNTQ GAEGVLKQYE DCLREVHSVP
SDIKQVETYR TKLKKMRTEA EGEQPIFDSL EEELKKATTV SNKMSRVHSD RDVELDHYRQ
QLSNLQDRWK AVFTQIDLRQ RELEQLGRQL RQYRDSYDWL IRWIADAKQR QEKIQAVPIS
DIKTLKEQLA QEKKLLEEIE DNKDKVDDCQ KYAKAYIDTI KDYELQLVAY NAQVEPLVSP
VKKTKLDSAS DNIIQEYVTL RTQYSELMTL TSQYIKFITD SQRRLEDDEK AAEKLKEEEQ
RKMAKMQAEL DKQKQLAEAH AKAIAKAEKE AQELKLRMQE EVCRRETAVV DAEKQKQNIQ
LELYELKKLS EEQIKDKSKQ VDDALQSRLK IEEEIRIIRL QLEATVTQKS TAESELKQLR
DKAAEAERLR QAAKEEAEKL RKQVNEETQK KRIAEEELIC KAEAEKEASR QKQKALEDLE
NLKRQAEEAE RQVKQAEFEK ERQLKVAHQA AQKSAAAELQ SKHLSFVEKT SKLEESLKQE
HGAVLQLQEE ATYLKRQQED AENAREEAEK ELEKWRQKAN EALRLRLQAE EEAHQKSLAQ
KEAEKQKEDA EREAKKRAKA EDSALKQKEM AENELERQRK IAESTAQQRL SAEQELIRLR
ADFDNAEQQR SLLDDELYRL KNEVIDAQQQ RKQLEDELAK VRSEMDLLGQ LKSKAEKESM
SNTEKSKQLL ETEAAKMRDL AEEASKLRAI AEEAKRQRQI AEEETARQRA EAERILKEKL
AAISDATRLK TEAEIALKEK EAENERLRRQ AEDEAYQRKA LEDQANQHKQ AIEEKIIQLK
KSSEAEMERQ RAIVDDTLKQ RRVVEEEIRI IKLNFEKASS GKLDLELELN KLKNIAEETQ
QSKLRAEDEA EKLRKLALEE EKKRRDAEDK VKKIAAAEEE AARQCKVAQE ELERLRKKAE
EAKKQKDEAE QEAETQIVMA QQAAQKCSAA EQQVQSVLAQ QKEDTVVQKK LKDDYEKAKK
LAKEAEAARE RAEREAALLR NQAEEAERQK AAAEEEAANQ AKAQEDAERL RKEAEFEAAK
RAQAEAAALK QKQLADAEMV KHKKLAEQTL KQKFQVEQEL TKVKLQLDET DNQKAVLDEE
LQRLKDEVDD AVKQKGQVEE ELFKVKIQME ELLKLKNRIE EENQRLIKKD NAQKFLAKEA
DNMKQLAEDA ARLSLEAREA ARMRQIAEDD LSQQRALADK MLKEKMQAIQ EASRLKAEAE
MLQRQNDLAQ EQTQKLLEDK QLMQQRLDEE TEEYQKSLEA ERKRQMEITA EAEKLKLQVS
QLSEAQAKAQ EEAKKFKKQA DSIASRLHET EMATKEKVTE VHKLELARMN TSKEADDLRT
AIAELEKEKA RLKLEAEELQ NKSKEMADAQ QKQIELEKTL LQQTFLSEKQ MLLEKERLIE
EEKKKLENQF EEEVKKAKAL QDEQERQRQQ MEDEKKKLQA TMNAALSKQK EAEKEMENKQ
KEMKELEEKR LEQERLLAEE NQKLREKLQQ LEAQKEQQPD NVHDKGLIEA TTVVTTESVY
NGQSAGDMVD SVDPLAFDGI RNKVPASRLH DLGLLPQKEF DQLKNGNTTV KELGETDNLK
KILKGKNCIA GILTPTNQKV SIYQASKEKK ITPGTAMVLL EAQAATGYIL DPIKNQKLTV
NEAVKEGVIG PELHNKMLLA ERAVIGYKDP YTDGKISVFE AMKKGLIEHD HAIRVLEAQR
ATGGIIDPIN SHRVPKEIAY KQGQYDTEMN KIMENPTDDT KGFFDPSTQE PLTYSELMGR
CTADPDTGLL LLPITDKAAH CSSIYTEEET KDVFNKTTVS VPFGRFQGKT VTIWEIINSE
YFTEEQKKDL LRQYKTGKIT IEKIIKIVIT VAEEKEKKKE ITFDGLRAPV PATELLESQI
INKDLYNKLH KGSTTVKEVS EMKPVQKALK GTNCIAGVLI DSSQETMSFY QAMKKDLMRP
GPALNMLEAQ AGTGFLIDPV RNQKYTVDEA VKAGVVGPEL HEKLLSAERA VTGYKDPYTG
KTVSLFQAMK KDLIPKEHGV RLLDAQMTSG GIIDPVNSHY IPHDVACKRN YFDDEMKQIL
SNPTDNTKCF FDPNTDENVT YSELFKRCVT DKKTGLPLLP LSDEAIKQSK EALAYNEAQT
KEVMTQATVE LDSGPFKGRK MTIWEIINSE YFTEEQRHDL LRQFRSGKIT IEKIIKIVIT
VVNEKEAKKQ EQFNFYGLRG PVPASCLYDS KIIDKPTFEL LQKGKTTPKQ VSENPDVNKY
LRGSESIAGI YVAPTKEKMS VYQAMKKKLL RHNTGLLLLE AQAATGFIVD PVKNQCASVD
EAVKSGVVGP ELHEKLLSAE KAVTGYKDPF TGNKISLFEA MQKDLILKEH AMPLLEAQLV
SGGIIDPVNG HRVSNEVAYR KNIFSQDMAK ALSEPTDDNK AFSDPETDDN VTYRQLKDKC
QRDPETGLFM LPLSKPQSPT VVEKTYLYTE EQTQSDLTNT QIDIPIEGLA DKSLNLWDVM
NSNLLPDQER QKLMDEYRSG KITKERMIII IIEIMEQREI IKNESPFTYQ TIRRRITIEE
LYNARIIDLE TYNLIKEGKR NIRDIMEMTN VKQYLYGTGC VAGVTTDSSS KISIYQAMKR
GFIKPEVALT LLEAQAATGF IIDPVNNETL TVDEAVRKGV VGPEIHDKLL SAERAVTGYK
DPYSGKIISL FQAMKKDLVP EDYALKMLEA QTATGGIIDP EFQFHLSADI ALQRGYINKE
TNERLTDSVQ GFVDPVTEEN LSYAQLLKRC KLDGGLRLLS LGDKRLMFKG LRKQITMEEL
IRSQIIDQQT VTELNEGLLS VEEVSSRLSK YLEGTSCISG VFLESTKERL SIYQAMKKNM
IRPGTAFELL EAQAATGYVI DPIKNLKLTV NEAVKMGIVG TEFKDKLLSA ERAVTGYRDP
YSGKTISLFQ AMKKGLILKD HGIRLLEAQI ATGGIIDPEE SHRVPVEVAY KRGFFDEEMN
EILTDPSDDT KGFFDPNTEE NLTYLGLMER CITDPVTGLV LLLLKEKKKE KHTSSKSSVR
KRRVVIVDPE TGREMTVYEA YRRGLIDQQT YLELAEQECE WEELTVTSSD GTVKSVIIDR
RSGRQYDVDD ALVRGFIDQN ALDSYRAGNL SITEFADMLS GNMGGFRSRS SSFGSTTGST
SSTPMSPIPT IKAPAVIWND PTEETGPIAG ILDIDTLEKV SVTEALHRSL VDNITGQRLL
EAQACTGGII DPANGERFPV SEAAEKGLVD KAMVDRLSLA QKAFMGFEDP RTKVKMSASQ
ALKKGWLYYE AGQRFLEVQY LTGGMIEPDV DSRVSLDDSI RKGVIDARTA QKLRDVGSYS
KYLTCPKTKL KISYRDAMDK SMVEEGSGLR LLEASSQSTK GLYSPYNASG PGSAYGSRSG
SRTGSRTGSR RGSIDAGSGF SMNFSSSSYT SSSTSYGHNS QILCSYFIV
//
