ID H2SAC8_TAKRU Unreviewed; 343 AA.
AC H2SAC8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Kininogen {ECO:0000313|Ensembl:ENSTRUP00000009354.3};
GN Name=LOC101067074 {ECO:0000313|Ensembl:ENSTRUP00000009354.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000009354.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000009354.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000009354.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2SAC8; -.
DR STRING; 31033.ENSTRUP00000009354; -.
DR Ensembl; ENSTRUT00000009409.3; ENSTRUP00000009354.3; ENSTRUG00000003951.3.
DR eggNOG; ENOG502RYAC; Eukaryota.
DR GeneTree; ENSGT00950000182930; -.
DR HOGENOM; CLU_807845_0_0_1; -.
DR InParanoid; H2SAC8; -.
DR OMA; CNATVHM; -.
DR OrthoDB; 5223498at2759; -.
DR TreeFam; TF351852; -.
DR Proteomes; UP000005226; Chromosome 20.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00042; CY; 1.
DR Gene3D; 3.10.450.10; -; 2.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR027358; Kininogen-type_cystatin_dom.
DR PANTHER; PTHR13814; FETUIN; 1.
DR PANTHER; PTHR13814:SF12; KININOGEN-1; 1.
DR Pfam; PF00031; Cystatin; 2.
DR SMART; SM00043; CY; 2.
DR SUPFAM; SSF54403; Cystatin/monellin; 2.
DR PROSITE; PS51647; CYSTATIN_KININOGEN; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..343
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025522150"
FT DOMAIN 29..132
FT /note="Cystatin kininogen-type"
FT /evidence="ECO:0000259|PROSITE:PS51647"
FT DOMAIN 148..253
FT /note="Cystatin kininogen-type"
FT /evidence="ECO:0000259|PROSITE:PS51647"
FT REGION 264..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 343 AA; 37329 MW; FF8F406A571FBBC2 CRC64;
MRSGLGLCVL GLLCLSSSVR AQEPVKVSCD DPSVEKAVSS AVEKFNEKLT TGNKLALFQI
QSASKTGSGA DAVYSLQFTS RRSDCPAGGI KPWTDCDYLP RRKSPVPCSA IVHVTATEVN
TRHVECQIDG HFTPEKAPCL GCEMEIDENS EDLKSPLSVS ITKYNSMSNS LHLFTLNSVG
YATRQVVAGF RFKIRFDMKK TTCAKSQHSD LSDLCVPDDQ NMEFANCNST VDVAPWRHEL
PQVQMECEEG MLIMPLIKRR PPGWTPLRKF EKPGSAAKEE SSEEDTAAAQ PSASPVVDVV
PDDPLHCPSK PWKVFNPPSP VAPTDAPNMT ADAPVLSDTD LLA
//
