ID H2SBP5_TAKRU Unreviewed; 2439 AA.
AC H2SBP5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Notch receptor 3 {ECO:0000313|Ensembl:ENSTRUP00000009824.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000009824.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000009824.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000009824.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 31033.ENSTRUP00000009824; -.
DR Ensembl; ENSTRUT00000009880.3; ENSTRUP00000009824.3; ENSTRUG00000004154.3.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000160234; -.
DR InParanoid; H2SBP5; -.
DR OMA; HGTCHDD; -.
DR TreeFam; TF351641; -.
DR Proteomes; UP000005226; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 27.
DR CDD; cd21704; JMTM_Notch3; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 35.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022331; Notch_3.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF30; DELTA-LIKE PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00008; EGF; 18.
DR Pfam; PF07645; EGF_CA; 4.
DR Pfam; PF12661; hEGF; 9.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 2.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01986; NOTCH3.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 35.
DR SMART; SM00179; EGF_CA; 34.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 16.
DR SUPFAM; SSF57184; Growth factor receptor domain; 6.
DR SUPFAM; SSF90193; Notch domain; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 22.
DR PROSITE; PS00022; EGF_1; 34.
DR PROSITE; PS01186; EGF_2; 30.
DR PROSITE; PS50026; EGF_3; 35.
DR PROSITE; PS01187; EGF_CA; 8.
DR PROSITE; PS50258; LNR; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..2439
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025411479"
FT DOMAIN 20..56
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 57..97
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 98..134
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 136..173
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 175..212
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 214..250
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 252..290
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 292..328
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 329..367
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 369..407
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 409..445
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 447..483
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 485..521
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 523..558
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 560..596
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 598..633
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 635..671
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 673..708
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 710..746
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 748..784
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 786..824
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 826..862
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 864..900
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 902..938
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 940..976
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 978..1014
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1016..1053
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1066..1101
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1103..1139
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1141..1177
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1179..1222
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1224..1262
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1264..1303
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1304..1340
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1343..1381
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1394..1440
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1469..1512
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1838..1870
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1905..1937
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1938..1970
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1971..2003
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 2046..2087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2296..2368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2380..2439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2296..2318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2328..2368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2387..2431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 389
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 392
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 409
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 412
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 426
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 464
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 46..55
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 87..96
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 124..133
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 163..172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 202..211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 240..249
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 280..289
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 318..327
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 338..355
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 357..366
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 373..386
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 380..395
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 397..406
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 413..424
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 418..433
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 435..444
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 451..462
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 456..471
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 473..482
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 511..520
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 527..537
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 548..557
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 586..595
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 602..612
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 623..632
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 661..670
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 677..687
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 698..707
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 736..745
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 774..783
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 795..812
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 814..823
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 852..861
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 890..899
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 928..937
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 966..975
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1004..1013
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1043..1052
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1091..1100
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1129..1138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1167..1176
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1212..1221
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1233..1250
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1252..1261
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1293..1302
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1330..1339
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1352..1369
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1371..1380
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2439 AA; 263698 MW; C7852E03A08EEDD6 CRC64;
MEGNILWIIL AFLLFMHICE GFRCLDRYRP CENGGTCLDS SSRCICHRGF IGPFCQHLDP
CHQSPCLNGA ACKSQVVNGV PQYSCVCQRG FRGQDCSLID ACATSPCANG ARCANWNNHY
NCSCPPGFQG KNCRNDIDEC RKPGICLNGG LCMNTHGSFR CQCQPGYSGR TCEVSTLPCA
PSQCLNGGTC RQTSDHSYEC ACLPGFEGHN CESNVDDCPG HKCMNGGKCV DGVNTYNCQC
PPEWTGQYCA EDVNECLMQP NACHNGGTCF NTIGAHTCVC VNGWTGDDCS ENIDDCAIAV
CFNGATCHDR VASFFCECPV GKTGLLCHLD DACVSNPCNE GAVCDTNPLN GRAICTCPAG
FVGGACNQDM DECSIGANPC EHFGKCLNTE GSFQCQCGRG YAGPRCEIDI NECLSMPCQN
DATCLDRIGE FTCICMPGYM GTYCEVDIDD CESNPCVNDG ICRDMVNGFT CTCQPGFTGT
MCQIDIDECA STPCQNGAKC YDRPNGFECR CAEGYEGTLC ESNINNCQPD PCHHGTCVDG
IASYTCNCEP GYTGYRCENQ LNECHSNPCQ NGGKCVDLVN KYICQCQHGT SGTNCEINFD
DCASNPCDYG ICKDGINRYD CVCKPGFTGS KCNVEIDECA SSPCRNGGTC VDEENGFHCQ
CPEGFKPPYC YSQVDECASS PCVHGSCRDD INGYRCDCEP GWVGKNCDLD RNDCLPSPCQ
NAGTCIDQLN GFTCKCRQGF RGNLCQVNIN ECGSSPCLNK GTCVDGVASF TCLCELPYSG
PTCAEVLTPC SPNPCANHAV CSHTPDYLGY QCNCQAGWQG QLCNIDVNEC ISNPCKNRGT
CTNTPGGYLC SCRAGFTGLT CETDINDCSP NPCLNGGSCI DGVNSFHCSC LPGFTGPRCA
VEINECQSSP CENGGTCTDY VNSYTCTCRP GFTGIHCETN IPDCTESSCF NGGTCTDKIN
GYSCTCRPGF TGSHCQYEVN ECDSQPCLNG GICQDALDSF RCSCPKGFFG NRCQTPVDWC
RRLSPCQNGG RCRQKDAAFV CECTHGWSGR YCDIRRVSCE TAARQRGIQT DELCHHGGHC
VNTGNTHYCK CPSDYTGSYC ESQVDHCEDK PCRNGATCRG YVGAYQCDCM PGYTGQNCEI
EINECQSHPC QNGGSCIDLV GHYICSCPPG TLGVLCEINE DDCAPPGLRG ASPKCLNNGT
CVDRVGGYRC NCPPGFTGER CEGDINECLS NPCSPSSSLD CIQLPNDYQC VCKPGFTGRR
CQNRFSVCES QPCQNGGACS VSSNSASGYI CTCQLGYSGP NCDRSMSCRE LPCYNGGSCT
LTVRGARCSC LKGFGGPQCQ HRSNEGCSSK PCRNDGLCTE ETTFPYFHCQ CQGGWTGKRC
EKTVLSLEPQ TPSCPLSDCH SKRNDTVCDK ECNTLPCDWD GGDCSLMMNP WSGCAHCWRS
FNNSQCDDSC NNAECLYDNF DCKAKEKVCN PIYEAYCIDH YADEQCDQGC NTEECGWDGL
DCAGKVPENL ADGVLVLVVL LPPEELLRTS TAFLQKLSVI LRTTLRFRLD TNGEAMIRPY
TRKEARLKRE LQPQQEVIGS IVYLEIDNRL CTETCFPTAD TAAKYLGALS AAEMLRFPYP
LKEVRVEDFN GVDPIPEWAK LMLVAIASLF LLIILMIGML ITRRKREHST LWFPEGFFLK
KEPSSNKNRR EPVGQDALGM KHMAKTVEES LLGDHSDQWM DSDCPEAKRI KVEEPSMLSD
SEDAVDSRQW TQHHLAAADI RVPPTMALTP PQGEFEGDCM DVNVRGPDGF TPLMLASFCG
GGFEPEVAED EENEECSANI ISDLIYQGAS LAAQTDRTGE TALHLAARYA RADAAKRLLD
AGADANAQDN TGRTPLHAAV AADAQGVFQI LIRNRATDLD SRMYDGSSAL ILAARLAVEG
MVEELITCHA DVNAVDELGK SALHWAAAVN NVDATVALLK NGANKDMQDL KEETPLFLAA
REGSCEAVRM LLAHFANREI TDHMDRLPRD IAQERMHHDI VQLLDEYNTV RSPQGHGGAG
HHLTGGHTLS PLMCPPSSFL PNLKTTPQGK KNRRPGAKGS SLGAQHAANL KESVKARNKK
LTLEMQNALL ESSVTLSPVD SLDSPHGGAT NAGYITNPTS PVAMQSPGLF HSSMSVPNTP
MVHNSMLEGG GPFAVSLAQL NDPGAGGMSL QGRMSMASDI SRGYVLSSGQ VGLNMGMVSP
VSVPFDWHSR MPPSSQCAQP VVNLIQNSQA AMHPQSPVMQ QQNMLMHQPQ MFRSGMLQPT
PVTSTPSISP VKLPSIAEQQ QQQQQQQQQQ QQQQQMPQLP SQPQPPAQLP QAATSAAQPA
QALPSQPSVS TAGTEDYPTP PSQHSYSSAL DATPKHYLHL PSEHPYLTPS PESSEPWSSP
SPHCVSDWSD STPSPAVAGP AQTQITQVPE ANGKMQMFA
//
