ID H2SD88_TAKRU Unreviewed; 323 AA.
AC H2SD88;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Nitrilase 1 {ECO:0000313|Ensembl:ENSTRUP00000010368.2};
GN Name=nit1 {ECO:0000313|Ensembl:ENSTRUP00000010368.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000010368.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000010368.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000010368.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the carbon-nitrogen hydrolase superfamily.
CC NIT1/NIT2 family. {ECO:0000256|ARBA:ARBA00010613}.
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DR RefSeq; XP_003978094.2; XM_003978045.2.
DR AlphaFoldDB; H2SD88; -.
DR STRING; 31033.ENSTRUP00000010368; -.
DR Ensembl; ENSTRUT00000010426.3; ENSTRUP00000010368.2; ENSTRUG00000004359.3.
DR GeneID; 101062364; -.
DR KEGG; tru:101062364; -.
DR CTD; 4817; -.
DR eggNOG; KOG0807; Eukaryota.
DR GeneTree; ENSGT00550000075099; -.
DR HOGENOM; CLU_030130_1_2_1; -.
DR InParanoid; H2SD88; -.
DR OMA; KRESWGH; -.
DR OrthoDB; 1365844at2759; -.
DR TreeFam; TF313080; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR CDD; cd07572; nit; 1.
DR Gene3D; 3.60.110.10; Carbon-nitrogen hydrolase; 1.
DR InterPro; IPR003010; C-N_Hydrolase.
DR InterPro; IPR036526; C-N_Hydrolase_sf.
DR InterPro; IPR045254; Nit1/2_C-N_Hydrolase.
DR InterPro; IPR001110; UPF0012_CS.
DR PANTHER; PTHR23088:SF27; DEAMINATED GLUTATHIONE AMIDASE; 1.
DR PANTHER; PTHR23088; NITRILASE-RELATED; 1.
DR Pfam; PF00795; CN_hydrolase; 1.
DR SUPFAM; SSF56317; Carbon-nitrogen hydrolase; 1.
DR PROSITE; PS50263; CN_HYDROLASE; 1.
DR PROSITE; PS01227; UPF0012; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 40..295
FT /note="CN hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS50263"
SQ SEQUENCE 323 AA; 35639 MW; 517A9F561FE5D450 CRC64;
MIKSLIPVTC ILATSRKCIG LFPACRQGLK QINRMSTSQW PLAAVCQMTA TPDKAANLSA
CTQLVEEAKE RGAAMVFLPE GFDYIGSSRE ETLSLSEPLT GDTITQYCQL ARKLGIWLSL
GGFHERGHDW GSDRRIYNSH VIIDEQGKTV SVYRKSHLFD MELPEKGVSL KESAFTISGP
SLVAPVQTPI GKVGLGICYD LRFPELSLAL QKDGGAQILT YPSAFTVATG RAHWEVLLRA
RAIENQCFVL AAAQVGQHHD KRASYGHALA VDPWGDVLAD CGGEKPGLML VELNMEKLDS
TRKHMPVQQH RRDTVFYHSL ERT
//
