ID   H2SE33_TAKRU            Unreviewed;       727 AA.
AC   H2SE33;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Cadherin 8 {ECO:0000313|Ensembl:ENSTRUP00000010664.3};
GN   Name=CDH8 {ECO:0000313|Ensembl:ENSTRUP00000010664.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000010664.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000010664.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000010664.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; H2SE33; -.
DR   STRING; 31033.ENSTRUP00000059985; -.
DR   Ensembl; ENSTRUT00000010722.3; ENSTRUP00000010664.3; ENSTRUG00000004490.3.
DR   GeneTree; ENSGT00940000153691; -.
DR   Proteomes; UP000005226; Chromosome 13.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 5.
DR   Gene3D; 2.60.40.60; Cadherins; 5.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   PANTHER; PTHR24027; CADHERIN-23; 1.
DR   PANTHER; PTHR24027:SF273; CADHERIN-8; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 5.
DR   SUPFAM; SSF49313; Cadherin-like; 5.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..727
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5025412534"
FT   TRANSMEM        612..641
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          89..169
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          170..278
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          279..390
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          391..495
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          495..617
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   727 AA;  80658 MW;  AF2803F2409B9CB7 CRC64;
     MLKRSEEMLM DLWISLLLVW ITSVPCVSLS PITSQSKSTQ TGGSAVVASG LGEGQRLLSR
     AKRGWVWNQM FVLEEFSGPD PILVGRLHTD LDVGGKSIKY ILAGEGAGTI FAINELTGDI
     HAMKRLDREE KAEYTLTAQV INAETDEPLE PPSEFIIKVQ DINDNPPQFV QAPYQASVPE
     MSAVGTPVTR VTATDADDPV YGNSAKLVYS ILEGQPYFSI DPNSATIKVA LQGMDREMRE
     EYLVVIQAKD MGGHMGGLSG TTTVTITLTD INDNPPKFSK NLYEFVIPED LPIGKMGGKV
     KANDRDTGEN SKSTYGIVEG DDQGVFEIIT DSQTQEGILQ LKKPLDYESK RAYNLKVEAT
     NVRSEPGSGP FKDTATVKIT VEDSDEPPVF SKPIYQLEVN ENAPINTIIG TVTARDPDST
     GSQVRYFIDR HTDLERQFNI NVDDGKITLA KLLDRETDMW HNITVTATEV RNHSQISRAI
     VAIRVMDIND NAPEFATEYE AFLCENGKPG QVIQTVSAVD KDDPIQGHYF NYRLVPEMLN
     NPNFTIKNNQ DNSISVLAKH DTFRRQKQEM YFLPIIVTDN GHPPMSSTNT LTIRVCGCSK
     DGIVQSCNVE AYVLPIGLSM GALIAILACI VLLLVIVVLF VTLRRHKNEP LIIKDDEDVR
     ENIIRYDDEG GGEEDTEAFD IATLQNPDGI NVTVRPDLWF LRKVPFWSFW FLCSPTCVLN
     ARGFDGF
//