ID H2SF70_TAKRU Unreviewed; 383 AA.
AC H2SF70;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=CWC25 spliceosome associated protein homolog {ECO:0000313|Ensembl:ENSTRUP00000011051.1};
GN Name=cwc25 {ECO:0000313|Ensembl:ENSTRUP00000011051.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000011051.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000011051.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000011051.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CWC25 family.
CC {ECO:0000256|ARBA:ARBA00006695}.
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DR RefSeq; XP_011610850.1; XM_011612548.1.
DR AlphaFoldDB; H2SF70; -.
DR STRING; 31033.ENSTRUP00000011051; -.
DR Ensembl; ENSTRUT00000011110.3; ENSTRUP00000011051.1; ENSTRUG00000004650.3.
DR GeneID; 101079310; -.
DR KEGG; tru:101079310; -.
DR CTD; 54883; -.
DR GeneTree; ENSGT00440000039055; -.
DR InParanoid; H2SF70; -.
DR OMA; SWHPHTM; -.
DR OrthoDB; 12277at2759; -.
DR Proteomes; UP000005226; Chromosome 17.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR019339; CIR_N_dom.
DR InterPro; IPR022209; CWC25.
DR PANTHER; PTHR16196; CELL CYCLE CONTROL PROTEIN CWF25; 1.
DR PANTHER; PTHR16196:SF0; PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG; 1.
DR Pfam; PF10197; Cir_N; 1.
DR Pfam; PF12542; CWC25; 1.
DR SMART; SM01083; Cir_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 11..47
FT /note="CBF1-interacting co-repressor CIR N-terminal"
FT /evidence="ECO:0000259|SMART:SM01083"
FT REGION 94..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 23..54
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 101..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..198
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 383 AA; 45447 MW; EA724B0C38E262F4 CRC64;
MGGGDLNLKK SWHPQTMKNI ERVWKAEQKH EAERKKIEEL QKELKDERNR EEITRFAEET
GAIKKRDDRL DWMYQGPAGH VSRDEYLLGR PIDKQITDQY EEPESGPSNE TGLLPGSIFN
PTTQASTLDL AAKIREDPLF AIRKREEEKK REVLTNPVKM RKIKEMLRQN LDKKDKKKKK
KKDKKERKGE RSKKDKKHKR RSSDSDEEDN KKYRSPDEAP VKKSHSRHVP GYGLQFPAGS
HFEASAPANL ARRRERSRSQ SPHRNHRDDR NRRSVSPPKQ RYQKQRNHAS KKLSSEEMEL
KRKEMMDQAK QREEDRENNV KRYKRQDEQE KQREKNAKYD RHAGFIHNMK LESAESSSLE
DRVKRNIHSI QRTPASLDNF MKR
//
