ID H2SGL7_TAKRU Unreviewed; 923 AA.
AC H2SGL7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=UNC5C {ECO:0000313|Ensembl:ENSTRUP00000011549.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000011549.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000011549.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000011549.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR AlphaFoldDB; H2SGL7; -.
DR STRING; 31033.ENSTRUP00000088381; -.
DR Ensembl; ENSTRUT00000011609.3; ENSTRUP00000011549.3; ENSTRUG00000004833.3.
DR GeneTree; ENSGT00950000182815; -.
DR Proteomes; UP000005226; Chromosome 21.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF7; NETRIN RECEPTOR UNC5C; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT CHAIN 24..923
FT /note="Netrin receptor UNC5"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT /id="PRO_5025715342"
FT TRANSMEM 371..396
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 158..239
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 527..661
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
SQ SEQUENCE 923 AA; 102851 MW; 14D63794F5ACD425 CRC64;
CLVCFFFSSQ LLFVLLLKIK VLILNVAPLS ELPETFPSDP PEPLPHFLFE PEEGYIVKNK
PVNLYCKATP ATQIYFKCNS EWVHQKDHTV EERVDENSGL VVREASIEIT RQQVEELFGP
EDYWCQCVAW SSAGTTKSRK AHVRLAYLKK TFDQEPLGKE VSLEQEVLLQ CRPPQGIPAA
EVEWLKNEEI IDPAEDRNFY ITIDHNLIIK QARLSDTANY TCVAKNIVAK RRSTTATVIV
YVNGGWSTWT EWSVCNSRCG RGFQKRTRSC TNPAPLNGGL PCDGQAIQKL TCTTLCTVDG
EWTDWSKWSA CGTECTQWRR RDCNNPAPKN GGKDCEGLVL QSQNCTDGLC MQSEWTLTTR
VPMTAPSTDD VALYVGIVIA VIMCLVISVI VALFVYRKTH RDFDSDIIDT SALNGGFQSV
NIKTARSADL LTAPPDLTNA AAMYRGPVYA LHDVSDKIPM TNSPLLDPLP NLKIKVYNSS
GLVTPQDDLG GDFTAKLSPK VTQTLLDNSD TMNLRNQSLA RTRDPSCTAH GSFNNHGGHL
IVPNSGVSLL VPAGAVPQGR VYEMYVTVHR KDSVRPPVED TQTLLSPVVS CGPPGALLTR
PVILTIHHCA DNVEEDWLIQ LRNQLAMGEW EDVVVVGEEN FTTPCYVQMD SEACHILTET
LGTYCLVGQS ICKAAAKRLK LAVFGPVCCT TLDYHIRVYC LDDNQDALKE VLQMETQMGG
KLLDEPKTLN FKDSTHNLRL SIHDVPHTHW KSKLIAKYQE IPFYQVWAGS QRTLHCTFTL
ERLSSATAEI SCKLCVRQVE GEGQIFQLSN TLEEVSPCID TSLMDPASNI TTLVGPNAFR
IPLSIRQKLC GSLDAPQTRG NDWRMLAHKL NLDRYLNYFA TKSSPTGVIL DLWEAQHFPD
GDLNELAAVL EEMGPKLAKH RKR
//
