ID H2SIS0_TAKRU Unreviewed; 1353 AA.
AC H2SIS0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=NPC1 like intracellular cholesterol transporter 1 {ECO:0000313|Ensembl:ENSTRUP00000012302.3};
GN Name=NPC1L1 {ECO:0000313|Ensembl:ENSTRUP00000012302.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000012302.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000012302.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000012302.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR RefSeq; XP_011616869.1; XM_011618567.1.
DR STRING; 31033.ENSTRUP00000012302; -.
DR Ensembl; ENSTRUT00000012362.3; ENSTRUP00000012302.3; ENSTRUG00000005135.3.
DR GeneID; 101061759; -.
DR KEGG; tru:101061759; -.
DR CTD; 29881; -.
DR eggNOG; KOG1933; Eukaryota.
DR GeneTree; ENSGT00940000159904; -.
DR HOGENOM; CLU_002359_0_0_1; -.
DR InParanoid; H2SIS0; -.
DR OMA; VSLHCQN; -.
DR OrthoDB; 2786103at2759; -.
DR TreeFam; TF300416; -.
DR Proteomes; UP000005226; Chromosome 21.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0030301; P:cholesterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF3; NPC1-LIKE INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1353
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025582558"
FT TRANSMEM 282..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 713..736
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..814
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1131..1152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1159..1180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1186..1209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1230..1249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1261..1285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 649..814
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1304..1353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1319..1346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1353 AA; 150105 MW; 31C7A0DFB101DC53 CRC64;
MICFTLLLFL ARALPSGAQE EPGSCAFYEE CGLNPLLEGT GTLIDPIVPC LNSTRPPLLS
GGHYKKLKEV CPMLDKGEAN TYACCSEKQL NSLEKSLSLS KVVLIRCPSC ADNFAHLHCI
TTCSPQQTKT IQVTKVMNVT GNDKITREAV VGYTAFLGTT FADASFQSCK NVRIPATGGF
AIATMCGRYG SKLCNAQRWY DFQGDSSNGL APLDIDFRLL QPGHSEELPE GIVPYGGKAL
KCNEITPSGE KACSCQDCQE ACPKISSPPP PPGPFQLLGI DGFLVISIIL LCILIVAFLL
YVCVTRSMRS KRPGKRKKKP QVNEQKPAAV AQPVIHPSEV TCADKNSQLA QDFLSSKFQI
WGTIMATYPL TVLLLSAVTV AILSAGLKSI ELTTDPVDLW SAPNSRARQE KAFHDTNFDP
FFRTNQLILT APGREGQVYD SLLFGQNNLS GIISKDLIIE LLQLQTRIQN IEFWSEDLNR
TASLKDVCFA PLNPTNTSLT DCAVNSLPQY FQNNLTHINL KVNMTELGVT KEVDWRDHLI
YCFNSPLSFK DITDLGLSCM ADYGAPVFPF LAVGGYQNED FTNAEALLLT FSLNNYPRHS
AKFKVAMQWE TEFLKIVQEY QRNTSNSFTF AYMAERSLED EINRTTAEDI PIFMISYAVI
FVYIAVALGE YTSWRRILVD SKFLVGLGGI LVVGCAVVAS MGFYSWIGIP SSLIILQVVP
FLVLAVGADN IFIFVLEYQR DVRRPGEKRE EQIGRVLGTV APSMLLCSLS ESICFFLGAL
STMPAVKSFA LYAALAILLD FVLQMTAFVA LLSLDCRRQD SNRCELLSCI KVSTPRLNKP
NEGVLMPFMR KYYAPALLNR YSRILVMFVF IFMLCASIFL LFHVKVGLDQ ELAMPQDSYM
LKYFEYLYKY FKVGAPVYFV TTKGFDFSSV NGMNAVCSSV GCDPYSLTQK IQYATDYSQL
SYIGIPSNSW VDDFIDWLNP ASRCCRLYTT GQNFGKFCPA SEPATKCLLK CMNPSLDGVL
RPSVSQFNRY LTDFLGNRPD LQCPKGGLGA YDKAVVRDEN GEIIASRFMA YHTPLTNSQE
FTRALLKARE LAHNITLGMR QIPGTDPQFE VFPYTVTNVF YEQYLTIVPE GLFIVSLCLL
PTFVVCCLLL GLDLRSGLLN LLTIVMITVD TVGVMTLWGI DYNAVALINL VTAVGISVEF
VSHMTRSFAL SVQPSHVERA KEATAKMGSA VFAGVAMTNL PGILVLAFAK AQLIQIFFFR
LNLVITLLGL VHGLVFLPVL LSYFGPGVNK AVLLRLQQED LRTTKQLEMG PESNPGHQNW
GFEEDEKKPE GKPTASEAED RRSQSKQEMV NYF
//
