ID H2SJ54_TAKRU Unreviewed; 870 AA.
AC H2SJ54;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Extended synaptotagmin 2 {ECO:0000313|Ensembl:ENSTRUP00000012437.3};
GN Name=ESYT2 {ECO:0000313|Ensembl:ENSTRUP00000012437.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000012437.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000012437.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000012437.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}.
CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the extended synaptotagmin family.
CC {ECO:0000256|ARBA:ARBA00005867}.
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DR AlphaFoldDB; H2SJ54; -.
DR STRING; 31033.ENSTRUP00000087902; -.
DR Ensembl; ENSTRUT00000012497.3; ENSTRUP00000012437.3; ENSTRUG00000005185.3.
DR GeneTree; ENSGT00940000156086; -.
DR Proteomes; UP000005226; Chromosome 22.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0061817; P:endoplasmic reticulum-plasma membrane tethering; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd08391; C2A_C2C_Synaptotagmin_like; 1.
DR CDD; cd04030; C2C_KIAA1228; 1.
DR Gene3D; 2.60.40.150; C2 domain; 3.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037752; C2C_KIAA1228.
DR InterPro; IPR037733; Ext_Synaptotagmin_C2A.
DR InterPro; IPR031468; SMP_LBD.
DR InterPro; IPR039010; Synaptotagmin_SMP.
DR PANTHER; PTHR45761:SF2; EXTENDED SYNAPTOTAGMIN-2; 1.
DR PANTHER; PTHR45761; EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF17047; SMP_LBD; 1.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51847; SMP; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023055}.
FT TRANSMEM 54..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 125..304
FT /note="SMP-LTD"
FT /evidence="ECO:0000259|PROSITE:PS51847"
FT DOMAIN 303..424
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 711..839
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 870 AA; 97551 MW; C9F363B4F08548BB CRC64;
MEGPGVGTNG PLPAPRNSVS STTGPPLPPD QLHEEPQSSL TDLIHMWIKF GKTFAIIFPI
YVLGYLEFSF SWVLVGLAML FYWRKNHGNK DYRINRALAF LEHEEKAVKQ SVPTTDLPPW
VHYPDVERTE WLNKTVKQMW PFICQFVDKL FRETIEPAVK GANPHLSSFC FTKIDMGQKP
LRVNGVKVYT ENVDKRQIIM DLQISFVGNT EIDVDIKKYY CRAGIKSIQL HGTLRVVMEP
LLGDMPLVGA LSVFFLKKPL LDINWTGLTN VLDIPGVNGL CDNIIQDIIC TYLVLPNRIS
IPLVGESQLA QLRFPVPKVT GLRIHSLEAQ DLLGKDKFLG GLIKGKSDPY GVLRFGTELF
QSKVIHETVN PKWTEVYEAL IYENTGKNLE IELFDEDTDK DDFLGCLMID LAQIQQQQKI
DEWFSLEDVP QGKLHLRLDW LTPLATPDKL DQALISIKAE PHKANDGLSA ALLVVFLDSA
RNLPVSRQLD VACGRFLPCF ISSLSLFPTR YKTNEPVWEE THTFLIHKPP KPKSWSTIAR
WETLTLPLTR LLEAEDMTLN QRFPLKNSGP SCTLKMKDCP AGRTNVLYFD TDSSPSSEVP
SSPLKTQNSS NPTPRPSVSS DPHRLPEVSG APSVSPQDLQ AQRSVGNLGD NLADIGRSTG
NLASSGSQQY QPGGKEPTPS IASDISNPYA AQELQQRLQQ LQNGSGPGYF PLGQIQLTVR
HSSQRNKLIV VVHSCRNLIA FTDHGSDPYV RLYLLPDKRR SGRRKTHTLK RNLNPVYDQT
FEFTVSLVEL HRRTLDVAVK NGGSLLSKHK GLLGKVRLSL GYQGNVFKLK HIKVFSLLSG
SGRFDPRGHQ QRLHTMVGLP HQHQHAAHTL
//
