ID H2SJS1_TAKRU Unreviewed; 1093 AA.
AC H2SJS1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRIK5 {ECO:0000313|Ensembl:ENSTRUP00000012654.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000012654.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000012654.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000012654.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR AlphaFoldDB; H2SJS1; -.
DR STRING; 31033.ENSTRUP00000012654; -.
DR Ensembl; ENSTRUT00000012715.3; ENSTRUP00000012654.3; ENSTRUG00000003234.3.
DR eggNOG; KOG1052; Eukaryota.
DR GeneTree; ENSGT00940000158852; -.
DR InParanoid; H2SJS1; -.
DR OMA; SQYCNGY; -.
DR OrthoDB; 511851at2759; -.
DR TreeFam; TF334668; -.
DR Proteomes; UP000005226; Chromosome 12.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF351; GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|RuleBase:RU367118};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT CHAIN 28..1093
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT /id="PRO_5027140966"
FT TRANSMEM 554..573
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 633..654
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 813..837
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 425..794
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 435..499
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 988..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1017..1033
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1064..1085
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1093 AA; 121192 MW; BC5017A61C9BF80B CRC64;
MPALPALLLS YVFIPLLTVA PLPFAWADTP AALRMAAILD DQSLCGRGER LALALARENA
NSLMEGSSQS RVEVDIYELK NDSQYTTTDT MCQILPKGVV SVIGPASSPA SSSAVSHICG
EKEIPHVKIG PEETPKLPYL RFASVTLHPS NEDLSLAIGS ILRSFSYPTT SIICAKAECL
LRLEELVQSF LISRETLSVR MLDDSLDPTP LLKEIRDDKV ATIIIDANAS VSYRILKKAN
ELGMMSAFYK YILTTMDFPL LWLDNVVGDQ SNVLGFSMLN SSHVFYLDFI RSLNLSWREG
CRINPYPGPA LSSALMFDAV HVVVSAVRQL NRSQEIGVRP LSCTSPLIWQ HGTSLMNYLR
MVEHDGLTGH IEFNSRGQRT NYTLRILERH PGGHKEIGTW FSNNTLVMNS TSLDLNASET
LANKTLTVTT ILENPYVMRK SNHQDFQGNN QYEGFCVDML RELADILKFS FKIKLVDDGL
YGAPEPNGSW TGMVGELINR KADLAVAGFT ITSEREKVID FSKPFMNLGI SILYRVHLGR
KPGYFSFLDP FSPAVWLFML LAYLAVSCVL FLAARLSPYE WYNPHPCLRE RRDILENQYT
LGNSLWFPVG GFMQQGSEVM PRALSTRCVS GVWWAFTLII ISSYTANLAA FLTVQRMEAP
IESPDDLADQ TNIQYGTIHG GSTMTFFMNS RYQTYQRMWN YMYSKQPSVF VKSTEEGIAR
VLNSRYAFLM ESTMNEYYRS LNCNLTQIGG LLDTKGYGIG MPLGSPFRDE ITLGILQLQE
SNRLEILKRR WWEGGQCLRE EDHRAKGLGM ENIGGIFVVL ICGLIIAVFV AIMEFVWSTR
RSADTDEVSV CQEMLSEFRN AVCCKKSSRS RRRRPLTGAG VGVLRHPSRL ALAAPRPIRL
VRDMRFSNGK LYGGAGRLSG TPRGVGGADL GPGPQKLLEE PMCVNATGSA LTPPLPTLVA
PPMLPRGFLQ GCSHVRICQE CRRIQNLRPT ALTPPPPPPP SSSSSTSSCS RVPASAPHRR
HGLHHHLHHH RGSMSLPRLP PPSTPSPTDR ADSDGGGTGS PRRASMKPPP PPRPMPPPKT
PPRPPTDLLG GHN
//