ID H2SKY2_TAKRU Unreviewed; 457 AA.
AC H2SKY2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Ras association domain-containing protein 8-like {ECO:0000313|Ensembl:ENSTRUP00000013066.2};
GN Name=RASSF8 {ECO:0000313|Ensembl:ENSTRUP00000013066.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000013066.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000013066.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000013066.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_011605453.1; XM_011607151.1.
DR AlphaFoldDB; H2SKY2; -.
DR STRING; 31033.ENSTRUP00000013066; -.
DR Ensembl; ENSTRUT00000013127.3; ENSTRUP00000013066.2; ENSTRUG00000005443.3.
DR GeneID; 101077935; -.
DR KEGG; tru:101077935; -.
DR eggNOG; KOG1574; Eukaryota.
DR GeneTree; ENSGT00950000182839; -.
DR InParanoid; H2SKY2; -.
DR OMA; IQDMQHE; -.
DR OrthoDB; 5354728at2759; -.
DR TreeFam; TF318385; -.
DR Proteomes; UP000005226; Chromosome 9.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16134; RA_RASSF8; 1.
DR InterPro; IPR033593; N-RASSF.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR048945; RASSF8/10_RA.
DR InterPro; IPR048944; RASSF8_RA.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR15286:SF12; RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 8-LIKE ISOFORM X1; 1.
DR PANTHER; PTHR15286; RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF21712; ASPP1-2_RA; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 1..82
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 81..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 192..219
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 261..291
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 115..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 457 AA; 51331 MW; 39F511CB6F0E34EA CRC64;
MELKVWVDGV QRVVCGVTEA TTCQEVVIAL AQAIGRTGRY TLIEKWRDTE RHLAPHESPV
ASLNTWGQYA GDVQLILHRT GPSLTERPPS EGPPLRGPER GLHRQSLPPL AKLRHPNDRS
LRRREPRRKS LTFTGAHRGL REILSGGQIG EAEAKRRLLQ GNGGNFHHVG ATLGTASPGL
WACRMEDLVR LVSLQRETLD VLEKKLETYE AELQAWADGR GERGGRSSGE PGGGRLMDEI
LRLEKHLRKN EVEMEEEEFW ATELQIELES ERQLEERLQE LRGRLHGCEL DIEEKLAMVQ
SVEAGLEEQR LQQERQETQW VSEAEARAQV LRAKTELKSQ ERQAVQLESS SRAVDRSLGQ
SNKKLQDMQH ELELLTKELR QVNLQQFIKQ TGTKVTVLPA EPGEEEGSNS SQTSQTKDVV
LLTGSLKRPA ASRPTSSHLR VLHSPLSSGL NPEGIYV
//
