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Database: UniProt
Entry: H2SL25_TAKRU
LinkDB: H2SL25_TAKRU
Original site: H2SL25_TAKRU 
ID   H2SL25_TAKRU            Unreviewed;      4580 AA.
AC   H2SL25;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   16-JAN-2019, entry version 44.
DE   SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSTRUP00000013110};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000013110, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000013110}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000013110}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   STRING; 31033.ENSTRUP00000013110; -.
DR   Ensembl; ENSTRUT00000013171; ENSTRUP00000013110; ENSTRUG00000005462.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000154906; -.
DR   InParanoid; H2SL25; -.
DR   OMA; THEKWSL; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000005226; Chromosome 4.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 4.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 3.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3993   4016       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4173   4192       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4212   4235       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4400   4422       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4477   4495       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      132    185       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      193    248       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      254    309       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      319    377       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      573    771       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      931   1119       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1233   1444       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3756   3791       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4580 AA;  517569 MW;  EBA49414F4481871 CRC64;
     LQSTFTSQGE HVKICLAAEG FGTRLCRLEP VSNCKNVPPD MSVCGFILAN CLSVRALHEM
     LSHTEHLAAE VRLYSHTTEN CTRFTLLSFL CCLSSSRSST DKLAFDVGLR EEKGGETCWW
     IVHPSSRQRS EGEKVRVGDD LILVNMSSER YLHLSAGSGF DSRSVIDSLS VNASFQQTLW
     SVAPIYCGGG VAQGYLKGGD TFWLHHSHSD ACLTIPSTEQ GEEPQKVMHY ETESVSCHAR
     SLWRLETLHV VWSGSHTYWG QPFRLCHVTT GRYMGLTEEK GLHLVDRDKA DVKTTSFCFR
     SSKEKLDSCV KTNIDGMGSP AIKYGDSVCY VQHVDSGLWL TYQSVDAKSS RIGTTQKKRA
     ILHSEGHMDD GLTLSRCQRE ESHTARLIRS ASLLFTHFVR KLDNCTHGNH TSVGLTRELL
     GHSLQDLINY FQPTVETLDH EATQHTMVVL KNRQNMFQEE GVIDLVLDCI DHLHQHIGAS
     QWDSEEEVET SLNGFYKLLA VLLRGNRVNC AHFSTSIDWL ISRLDWLEAS TGVLEVLQCV
     LLESPEAINA IKEIHIHSVI SFLEKHGFNH KVLEVLCSLC VCHGVAVRYN QNLICDKLLP
     DRDLLLQTRL INQVTSMRPN IFLFLGDDSA QHRRWYYEVV VDDLDPFVTS EPTHLRVGWA
     STEGYRPRPS GGEGWGGNGV GDDLCSYGFD GLHLWSGGVG RRVSSPFPHS LKDGDVVSCC
     LDLSAPCISF RVNGLPVQGM LENFVAEGLL HPVVSFSAGV KIRFLFGGQH GEFRFLPPPG
     FTPCSDALLP KVKLTVEACQ THILNHGEGQ HDLFGPLIPS TPVVFIPAPV DISKVPLPPQ
     LEDIREKMVV RLLAENDHNI WARERIKQGW TYGTQQVYVL CHFYCYPGSA EEKVKFLSFI
     EFLLFLSDSV LIAFAVKKNA HSHNMLTHDV KAKRSPCLVP YSFLDQRTRK VGRDRVREVV
     GTLLALGYTS LSNPCLFSAE KYRVFRPDKS HTVSTGKWYF EFEAVTAGKM RVGWTRPSCT
     PDRELGSDDQ AFVFDGFEAQ WYHQGADPLG RPWQKGDVVG CLVDMDECTM MITLNGELLF
     DGRGSELAAK DFEISDGLLP VVSVGVNQVG RLNFGRCVAS LQYFTVYGQQ EGYHPFAANM
     ARDPALWISW QQPQFSSIMP DHPNVQVRYL VNGSVESLSS LRVSQRLCAH HNGGSEISFF
     RLSMHIECAS VLVSPVGGVL PIASNSLSPG RKELEEVDSD FEVLRKSALT FAGSRDELNH
     KDHNQEKTSR LKHRFMLKRS KPGLVSSNSS ARLLEDVVIK RTTFVFQYYY SVRVLPGQEP
     FNVWVGWVTS NFHQHEATFD PDNVHTVTVT LGDESGKVRE SVKRSVCYMV CAGEATGLSQ
     SRRSSGLEIS CLIDTDTGLL TFTSNGVEMS TFFQVEACTK LFPAVFVRPT TNSMFQFEFG
     CIKNAMPLSA GLLRSQRCNT APHCPPRIQV QQLKPVSWTR LPSQAVKVNV DQPDVYRGWR
     IQCSEALQAM NLQIPDENRS FDILELSELE DLLTFHHHTL RLYCSLCSLG NSRVSHAICS
     YMDQSQILHA IQNPHLPGLL RSVFYELLIQ VHLSSHTTAY LMMNHEYIVP MTAKARDITL
     YPSSFTGDNG GTGISNFSHG TSLKPQMHSS SPSFVQIYEG NYAAEIAQED SPEFPLDVLK
     NLTVQMLTEA VDVLRQNLRD PVGGNIELLL VPLLKLVYSL LVMGVLEDED LGKVLRLLDS
     GVFFTNPQSP KDKEKEVECD DEKEYSDSQQ QKEYDHKVGL LQMKLPEPVK LELCRLLSYL
     CDCQMRQRVE AVAAFSDSFV VQLQENQRFR YNEVMQALNM SAALTARKTK EFRSPPWEQI
     NMLLRFRDDG VSCPCPVEIQ ELLQEFHHLL KTHCESDGEG EEVAEASVKN LLLSQVAKVI
     GLKIKPFEVA ESKAVNTKTL KDLISKTMVH WSQEAKMQDP ELVRAVFSLL HCQYQGLGGQ
     MAGPLSRTYS ISLTSVDDTM ALLSSLSQIR SLLCVCMGKE EEKLMIRKLG DIINNKVFYQ
     HPDLMRTLGM HETVMEVMVN VLGEGESKEI TFPKMVASCC RFLCYFCRIS RHNQGALFDH
     LSYLLENSSV GLASPSMRGA TPLDVAAASV MDNNELALAL TESDLQKVIQ YLASCGLKSC
     PMLLAKGYPD IGWNPVEGER YLDFLRFAVF CNGESVEENA YMVLRLLIRR PECFGPALQG
     DGGTGLLAAM REAIRISDDP SIDRSSCPHQ ANRTIDVVQD NGDDLIHMGH AILTFYSALI
     DLLGRCAPEM HLIQGGRGDA LRIRAILRSL VPVHDLEGVI SSSFCVPSAS KDGCGIVEPN
     LSTVFCPDHK AAMVLFLDRV YGIEKQSFLL HLIEVGFLPD LQAAVSLDTV ELASTDMALA
     LNRYLCASVL PLLTKYSALF CHLEDHILLV DSLIQAIYSL SNALSLTKAQ RDTIEDCLLA
     LCSKLQPSLM QPLLRRLVFD VLHLTEYNKL ALKLLTSHYE QRSQYYLMVG ELSHHSLASE
     EELHLSQKLY WRVFKAVNKK PYEPQLFRLC VQCLAAVANA LPPDHSDTGY QSQAEGKASA
     DTDGQFDPQP IDTSNVSVPE RLEFIVNKYA EHTHEKWSLD KFANGWVHGE QLCENSKIHP
     LLKPYRALAE KEKEAYRCAI KETIKSMLAF GWTIERTKEG EARDVHTCTR RVSQSGQQLS
     FEGASTFSPK ATDMSAITLS WDQCTMAEQL AENYHSSWAK RRKLDYETRG GGGHSMIVPY
     DTLTAKEKTK FRERAQDILK FLHLNGYTVW RDRRTVEVDF PAVANCFGST LLKQFLSHTE
     NAQEHMLELV DAGLLSVLQV ILPLLEEYMR THRLYFLSSS MSSRGKRGHA SNKEKEMIAS
     LFCKIAELIR HRLPLFDLIK CSFFSRTLMK SAPESVHSSL NSFFETSAAD LEMTVENLSM
     NMACLPQIRN QHARGAARVL SHTSSVLLPM LTSLFQHLGL QNYGGDLLVG SIQVSCYRIL
     NSLYTLGTTS SLYMEEQRPA AGACLAALTG TFPVCFLEPA LNQNNPYSIY NTICDVCPLL
     PSLEQALRDV KQLAGAGAGA RQTQYIHVTE VILPMLCSYM SFWWSWGPEG HPDSPMCTSV
     TPHHASDLLG HVLRIIHNHV GTSQGDWMKQ MAGIIGYLLK THFLPLMGKL KKRAESVLLE
     EERMKTEGGD TSEAELEIQQ KFMVLVADLY AFYPLLIPFV DSNRVHWWKE SNPEAEQLFL
     MVSEVFIFWA KSHNFKWEEQ NYVVQNEINS LLFLVNSDSL SKLNHEKRKM KKKGDRYSTH
     TSLIVASLKR LLPVGLRNCL LSDQSLITLA KNGFAQVKNN HSLLYPTQLL FSCVFLKPTR
     HKILSKQRKR AVVACLRMAP LYNLPRHRAV NLFLQGYNKT WISTEDHNFE EKLVEDLAVS
     AKLCGGGREE DDRGDGAKAI DPLLQLITLF GQTALMDRRC VCVCVCVLCC TKHFSWEFQE
     KELEKQKLLF QQARLHHRGA SEMVLQIISS CDFFFLKKML VYLIERRDLG FFQSTAALML
     SCSVLDLNAF ERQNKAEGLG MAMDESSADK VMPDKDVICD LFRFLQLLCE GHNSDFQNYL
     RTQTGNTFKT TLIAIESISD FYWYYSGKGV IDVHGQHNFF KAIGVSKQVF NTLTEYIQGP
     CAGNQESLAH SRLWDAVVGF LHVFAHMQMK LPQDSRQMDL LIELLDLQKD MVVFLLSMLE
     GNVVNGTIGK QMVDMLVESS GNVQMILKFF DMFLKLKDFT SSDVFRAYDP DFKGCISRKD
     FEKAMKSCKR FSHTETRFLI SCMETDDSEA VDYVAFVNRF NEPAQDIGFS IAVLLTNLSE
     HMPNDARLRT FLEVAESILT YFQPFLGRIE ILGSGKRMER VYFRISESSR TQWEKPQVKE
     SKRQFIFDVV NESGDKEKME MFVNFCEDTI FEMQLAAQLS GSGNEERRVE TRPETEDGLD
     SKGISVIYQW PLLISALSVR HVKTLMKMTL KDIFISAIFL LRFVFMAQIR CICIGIRSIL
     YVLYRAFLSG ELIEGAKKVR ILEMLGGILE PTLDEVTGGP SGDQLRKYSC SLTLQEETSA
     LLTLNASITK QFKKDKKICL LNICSKSPDS VCRGIDIEKK SEVIMMEPKW RAKSHPQKSE
     EPENQQSALW GIISTHNKSM LNYFARNYYN MRVLALFVTF AINFILLFYK VSDEEDGTVY
     FVLEESSGYM ESSLHFLAVV HTIISFFCII GYYCLKVPLV IFKREKEVAR KLEFDGLYVT
     KQPPEEDIKG QWDRLVVHTP SFPSNYWDKF VKRKVMDKYG ELYGCEKISN LLGLDQAALD
     CSSERKGRKR FSSVDMKYQL WKTGVVFTDN SFLYLAWYMI LSGLGHYNNF FFAAHLLDIA
     MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV VYLYTVLAFN FFRKFYNKSE DEDTQDMKCN
     DMFTCYMFHM YVGVRAGGGI GDEIEDPAGD EFEVERIVFD ITFFFFVIVI LLAIIQGETK
     CFICGIGNEY FDKVPHGFET HTLQEHNLAN YLFFLMYLIN KDETEYTGQE SYVWKMYQER
     SWEFFPVGDC FRKQYEDQLG
//
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