ID   H2SL78_TAKRU            Unreviewed;       774 AA.
AC   H2SL78;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=General transcription factor IIIC subunit 4 {ECO:0000313|Ensembl:ENSTRUP00000013163.3};
GN   Name=GTF3C4 {ECO:0000313|Ensembl:ENSTRUP00000013163.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000013163.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000013163.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000013163.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; H2SL78; -.
DR   STRING; 31033.ENSTRUP00000013163; -.
DR   Ensembl; ENSTRUT00000013224.3; ENSTRUP00000013163.3; ENSTRUG00000005482.3.
DR   eggNOG; ENOG502QTDJ; Eukaryota.
DR   GeneTree; ENSGT00390000011873; -.
DR   HOGENOM; CLU_018536_0_0_1; -.
DR   InParanoid; H2SL78; -.
DR   OMA; WKPSHED; -.
DR   OrthoDB; 5395638at2759; -.
DR   TreeFam; TF328412; -.
DR   Proteomes; UP000005226; Chromosome 6.
DR   GO; GO:0000127; C:transcription factor TFIIIC complex; IEA:InterPro.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IEA:InterPro.
DR   GO; GO:0006384; P:transcription initiation at RNA polymerase III promoter; IEA:InterPro.
DR   InterPro; IPR045803; DUF5921.
DR   InterPro; IPR044230; GTF3C4.
DR   InterPro; IPR024761; TFIIIC_delta_N.
DR   InterPro; IPR024764; TFIIIC_Znf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR15496:SF2; GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4; 1.
DR   PANTHER; PTHR15496; GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY; 1.
DR   Pfam; PF19336; DUF5921; 1.
DR   Pfam; PF12657; TFIIIC_delta; 1.
DR   Pfam; PF12660; zf-TFIIIC; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT   DOMAIN          58..499
FT                   /note="Transcription factor IIIC 90kDa subunit N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12657"
FT   DOMAIN          500..577
FT                   /note="DUF5921"
FT                   /evidence="ECO:0000259|Pfam:PF19336"
FT   DOMAIN          690..741
FT                   /note="Transcription factor IIIC putative zinc-finger"
FT                   /evidence="ECO:0000259|Pfam:PF12660"
FT   REGION          579..617
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        592..617
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   774 AA;  87141 MW;  CBA25636E058FE1B CRC64;
     MAASIPPDKA QSLPNNILIK EDPEAEECVN GSTEDCTIKR DPVVPLLSPV SGLQPLVWSE
     DHRLAVCTSG SLSVMELVCD VNNSNLDLTL HRTSIAVPTE AHRFQGGPAA EFAEAVEKFS
     THPDPYIRQV FLADTVMNPA LGGHKGIKHA AWSPLGCDLN GCCLLACLTL DNRLTIHNSH
     KRLEWNTLVN LSKKYSNRLK EQGYAGKDNK PPLANLLDFD ELQRRFRMQT PLRMEWSSIY
     TVKHFQPNNT CIDIEMVLLA VLMENGDLVL WKFVLPFLNG DGVEFFDLME SGVTSPSDLA
     WWEYENGERR MSGLIVGSEV GPVKIMPVSL PGVKGYFTLR HPIILWKECD EIAVGNLKCI
     SMVHPIQKTS CSLIVASRGC YVFWCLLMIS PAGLNVHNSH VAGLHSLPVL SLAVSRHGIA
     VYTCSIDGWI KKLTPTFTEN SLIFKQEDVV RPESITARRI HSIAVSYNGA YIALVSTQGM
     VCGYHPINRT YQVHFMTLKT PEMASALLLE SPIQNLYRMT DLLDLVRWQI LKDKCIPASL
     MDELEQKIRE TDSTYLWRFK LFLVRILCQS LQSPLTEHRW KPSQEGSQVV DSQDQEDTKD
     MEGSSYEEER SEVKQEATYE EKLAQTQALI GSIEKHLMRE NMKKVLGAVY LNTCITQNTS
     IPTCGLMEYL SGDANDRDLE VLIGHIKKKM AKQTFSEHCS LCREVLPFSD HKQTVCENGH
     LWLRCVLSHQ ACQSLTFRRC LLQDSIAKLP EPEEPEWIKK LLQAPCTLCD SPMI
//