ID   H2SN20_TAKRU            Unreviewed;       577 AA.
AC   H2SN20; H2SN21;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 70.
DE   SubName: Full=Myotubularin related protein 9 {ECO:0000313|Ensembl:ENSTRUP00000013806.2};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000013806.2, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000013806.2, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000013806.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR   AlphaFoldDB; H2SN20; -.
DR   STRING; 31033.ENSTRUP00000013806; -.
DR   Ensembl; ENSTRUT00000013869.3; ENSTRUP00000013806.2; ENSTRUG00000005696.3.
DR   eggNOG; KOG1089; Eukaryota.
DR   GeneTree; ENSGT00940000157818; -.
DR   InParanoid; H2SN20; -.
DR   OMA; ILKCKDF; -.
DR   TreeFam; TF315197; -.
DR   Proteomes; UP000005226; Chromosome 16.
DR   CDD; cd13211; PH-GRAM_MTMR9; 1.
DR   CDD; cd14536; PTP-MTMR9; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   PANTHER; PTHR10807:SF56; MYOTUBULARIN-RELATED PROTEIN 9; 1.
DR   Pfam; PF06602; Myotub-related; 1.
DR   Pfam; PF21098; PH-GRAM_MTMR6-like; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT   DOMAIN          123..526
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
SQ   SEQUENCE   577 AA;  66350 MW;  48167E9466A08FAE CRC64;
     MEFAELIKTP RVDGVVLHRP FMPTVEGTLC LTGHHLILSS RQDNIEELWL LHSNIDSIEK
     RFVGSLGSII VKCKDLRVIQ LDIPGMEECL NIASSIEALS TLDSLSLMYP FFYRPMFEVI
     EDGWKLFLPE EAFKDLESMV WRQLMFESYY SSAMCPRCLP FQYCVHQTDE WRLSDVNKDF
     SVCPSYPSLV AVPKNIDDEA LRKMATFRQG GRFPVLSYYH RKNGMVMMRA GQPLTGTNGR
     RCKEDEKLIN ATLRPGKRGY IIDTRAINVA QQAKARGGGF ESEANYPQWR RIHKAIERSN
     VLQESLIKLV EACNDQSHNM DRWLSKLEAS SWQSHVKEIL TTACLAAQCI DREGASVLVH
     GTEGTDSTLQ VTSLAQIILD PSRRTIRGFQ SLVEREWLQA GHPFQQRCAQ SAYSNSKPRQ
     EAPVFLLFLD CVWQILRQFP CSFEFNESFL LLLFEHTYAS QFGTFLGNYT AERVKVSLPE
     KTVSLWSWVN RPQELQRLTN PLYEANGLVI WPSVAPQSLL LWEGVFLRWN RSSQCLDEAY
     DEMVHIIEYN KELQNKVNSL RRQLAQLETQ DPLLQSP
//