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Database: UniProt
Entry: H2SNA3_TAKRU
LinkDB: H2SNA3_TAKRU
Original site: H2SNA3_TAKRU 
ID   H2SNA3_TAKRU            Unreviewed;      1946 AA.
AC   H2SNA3;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 43.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000013889, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000013889}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000013889}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   Ensembl; ENSTRUT00000013952; ENSTRUP00000013889; ENSTRUG00000005719.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    100    120       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    126    146       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    197    217       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    229    246       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    252    275       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    392    419       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    746    764       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    776    799       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    856    884       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    944    969       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    989   1011       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1170   1190       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1210   1228       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1235   1253       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1299   1322       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1409   1432       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1491   1509       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1555   1574       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1622   1644       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1712   1735       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      129    425       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      550    652       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      746    974       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      983   1165       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1169   1441       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1490   1745       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       15     35       {ECO:0000256|SAM:Coils}.
FT   COILED      441    461       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1946 AA;  221896 MW;  0F7D7CA862FED8E1 CRC64;
     KMAAMLLPTG PDGLRRFTRE SLAALERRIA EEQAKKAKGC HNTHKYADPL KPRIDLEAGK
     QLPRIYGDVP PELIGIPLED VDPFYYKNQR TFIVLNKGKA LFRFSATSAL YIFSPFHFLR
     AIAVRILVHS LFSLFIMFTI LTNCFFMAMS DPAPWTKYLE YTFTAIYTFE SVIKIFARGF
     CLVPFSFLRD PWNWLDFTVI VMAYVTEFVD LGNVSALRTF RVLRALKTIS VIPGLKTIVG
     ALIQSVRKLA DVMILTVFCL SVFALIGLQL FMGLLRQKCV RSLGHCINSS YSSTESFLCN
     NRTWSSQEDF LSSEENFYKI EGAKDALICG YGNDAGKCPD GFDCLKVGRN PNYGYTSFDT
     FGWAFLALFR LMTQDCWEKL FHQTLRSAGK TYMVFFVLVI FLGSFYLVNL ILAVVAMAYE
     EQNQATIAEA WQKEREFQMA MEHLRREQRA AKRQAQETDS VLSPELSPFY LKAGSIRRSS
     SRRRRSHRTL SEETAGEASE EKFDDPDEPI VHRPTFYFSP LVVVFSANPP SVCLQPPLSP
     LPAHPLLATL SAHPLSTRRG SQVSIFSSFR ARINSEADFG DDEYSVHGDA FRSRASSMAT
     PWKRRTGSVR SHCSQILNPS LNVNGRLNIS LDQNAVTTLG LHTPTSIPAP SMERVREDTR
     PTHAEDAAVR PLLQPSPTVT EPPTVHRKRG LSSVSFLSDA MDELEESRQK CHPCWYTFAK
     RYLIWECCPW WRQIKEWVKH MVMDPFLDLG ITICIVLNTL FMALEHYPMT EEFNTMLSVG
     NLVFTGIFTA EMVLKLIALD PYYYFQQGWN IFDGVIVCLS LMELGLSNVE GLSVLRSFRL
     LRVFKLAKSW PTLNTLIKII GNSVGALGNL TLVLAIIVFI FAVVGMQLFG KNYQDCVCKI
     SFDCQLPRWH MKDFFHSFLI VFRVLCGEWI ETMWDCMEVA GQPLCILVFM LVMVIGNLVV
     LNLFLALLLS SFSSDNLSAP DEDGDLNNIQ IAIARITVGV SWLVSSVTNV FNRRIKHRKP
     KSQETHQAVK LVVNHVECNG GIYGEKYVIP EEDSYMTNPN LTVIVPIAPG ESDVEFLEEE
     ENSDTSDDED NKEKYEEKIS LSEGSTVDLR KPGEELDNFS ELAEESMEPE ECFPEFCVRH
     CHCCHIDVTR GLGQAWWRLR KTCYQIVEHS WFETFIIFMI LLSSGALAFE DIYIEKRKVI
     KLVLEAADKV FSYIFVLEMF LKWIAYGFKK YFTNYWCWLD FLIVDVSLIS LAANSLGYSD
     FTAIKSLRTL RALRPLRALS RFEGMRVVVN ALIGAIPSIM NVLLVCLIFW LIFSIMGVNL
     FAGKFGKCVN RTGFIHSVSV VNNKSDCLAM NDTQFYWTKV KVNFDNVGIG YLSLLQVATF
     KGWMEIMHAA VDSRGVEEQP IREINIYMYL YFVVFIIFGS FFTLNLFIGV IIDNFNQQKR
     KLGGQDIFMT EEQKKYYNAM KKLGSKKPQK PIPRPTNIIQ AFFFDLVSKQ AFDIMIMMLI
     IVNMVTMMVE TDEQSEHMEA ILNKINHVFI VIFTTECLIK IFALRCYFFT IAWNIFDFVV
     IILSIVGIVL ADLIEKYFVS PTLFRVIRLA RIGRVLRLIR AAKGIRTLLF ALMMSMPALF
     NIGLLLFLVM FIYAIFGMAN FAYVKKQDGI DDMFNFETFG NSMICLFQIS TSAGWDNLLS
     PIMANSPTEC DVNFVNTGTN TRGNCGSPSM GIAFFVSYII ISFLIVVNMY IAIILENFSV
     ATEESTEPLS EDDFEMFYEV WEKFDSEATQ FIEFSMLSNF ADTLSEPLRI AKPNMIKLIS
     MDLPMVSGDR IHCLDILFAF TKRVLGESGE MDALKQQMEE KFMMTNPSKV SHEPITSTLR
     RKVEEVSATI IQRCYRRHLV RRQMKQASHL YRQINQETVV DVENALETEG LIASMIQHFG
     PVEVEVLETT ADTELSSPPS YESVTR
//
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