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Database: UniProt
Entry: H2SS87_TAKRU
LinkDB: H2SS87_TAKRU
Original site: H2SS87_TAKRU 
ID   H2SS87_TAKRU            Unreviewed;       978 AA.
AC   H2SS87;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   24-JAN-2024, entry version 72.
DE   RecName: Full=receptor protein serine/threonine kinase {ECO:0000256|ARBA:ARBA00012401};
DE            EC=2.7.11.30 {ECO:0000256|ARBA:ARBA00012401};
GN   Name=bmpr2 {ECO:0000313|Ensembl:ENSTRUP00000015274.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000015274.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000015274.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000015274.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC       {ECO:0000256|ARBA:ARBA00009605}.
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DR   AlphaFoldDB; H2SS87; -.
DR   STRING; 31033.ENSTRUP00000061028; -.
DR   Ensembl; ENSTRUT00000015343.3; ENSTRUP00000015274.3; ENSTRUG00000006256.3.
DR   eggNOG; KOG3653; Eukaryota.
DR   GeneTree; ENSGT00940000156449; -.
DR   TreeFam; TF314724; -.
DR   Proteomes; UP000005226; Chromosome 8.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   CDD; cd14054; STKc_BMPR2_AMHR2; 1.
DR   Gene3D; 2.10.60.10; CD59; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR000472; Activin_recp.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255:SF103; RECEPTOR PROTEIN SERINE/THREONINE KINASE; 1.
DR   PANTHER; PTHR23255; TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II; 1.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF57302; Snake toxin-like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        156..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          208..512
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          525..628
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          720..789
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          811..893
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          951..978
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        525..550
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        563..628
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        725..789
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        827..849
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        859..874
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        951..968
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         235
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   978 AA;  106987 MW;  C0547ED97FBDE915 CRC64;
     APPFPRNPTP SLPMNSAQIS VFPAAQGEER ECAFTDQQQQ WEVERMAGGE GRISPENTTV
     RCGKGSHCFG LWEKSPPGEV RLVKQGCWTH LGDHQGCRDD RCVVTNLPPQ IQNGTYHFCC
     CGSDMCNVNF TEDFPQPSPT TAQPIYSRTL GYEETVIITV ATVSVLAVLA VAAFFGYRMM
     HGDGKQGLHN LNMMEAAGSE SSLDLDNLKL LELIGRGRYG TVYCGSLDER PVAVKVFTAT
     NRQNFLNECS IYRLPLLEHD NIARFVAADE RTGSEGRTEY LLVMEYYPHG SLNRYLSVQT
     NDWVSSCRLA HSVTRGLAYL HTELFKGDLY KPAVSHRDLN SRNVLVKADG TCVIIDFGLS
     MKLTGNRPAR HGEEENAAIS EVGTIRYMAP EVLEGAVNLR DCESALKQVD MYALGLLYWE
     TFMRCTDLFP GEAVPEYQMA FQAETEAGNH PTFEDMQVLV SREKQRPKFP EAWKENSLAV
     RSLKETMEDC WDQDAEARLT AQCAEERLAE LLLIWDRSKS VSPTLNPMST TLHNERNRMT
     PKTGTYTDHP STYIEEHDGV AKNAQGDNTS SVTGRAGTGT GERNRNSINQ ERQQQANARL
     PSPEGSSTSM GLRGSPSTST TTTTIISESE GPVGVATVPA CLHLTQEDLE TTKLDPKEVD
     KNLKESSDEN LMEHSQKQFC SPDPLSPGSS SLLYPLIKMA TEASGVSDPA ASMPATIFPL
     PKQQNLPKRP SSLQLRTKPT KKESSSSSLR FKFGRSGKSN LRQVEGSKIN IGSGAGTNVA
     ADAQESTSTN NTPALREVHL NGNINGVVNG HANAGIPPMP SGGMASFGGT GTAQSDPASS
     RTDDGHLSLG TITASPDEHE PLLSREREQL DRRDAPSSVA ALRSARPNTN NNNRSAPFVR
     NVILIKVLSC LPGVQPDAVL EGAGEKIKKR VKTPYSLKKW RPTTWVISTD ARGPEVNNNG
     SAHVLPVPTT TMVSKRKR
//
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