ID   H2SSW4_TAKRU            Unreviewed;       708 AA.
AC   H2SSW4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Rho related BTB domain containing 2a {ECO:0000313|Ensembl:ENSTRUP00000015501.3};
GN   Name=RHOBTB2 {ECO:0000313|Ensembl:ENSTRUP00000015501.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000015501.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000015501.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000015501.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; H2SSW4; -.
DR   Ensembl; ENSTRUT00000015570.3; ENSTRUP00000015501.3; ENSTRUG00000004216.3.
DR   GeneTree; ENSGT00940000158918; -.
DR   HOGENOM; CLU_015517_0_0_1; -.
DR   InParanoid; H2SSW4; -.
DR   OMA; TIDKDCN; -.
DR   Proteomes; UP000005226; Chromosome 21.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd18359; BTB2_POZ_RHOBTB2; 1.
DR   CDD; cd01873; RhoBTB; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   PANTHER; PTHR24072; RHO FAMILY GTPASE; 1.
DR   PANTHER; PTHR24072:SF137; RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF00651; BTB; 2.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00225; BTB; 2.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00173; RAS; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF54695; POZ domain; 2.
DR   PROSITE; PS50097; BTB; 2.
DR   PROSITE; PS51419; RAB; 1.
DR   PROSITE; PS51421; RAS; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   4: Predicted;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT   DOMAIN          277..427
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|PROSITE:PS50097"
FT   DOMAIN          485..552
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|PROSITE:PS50097"
SQ   SEQUENCE   708 AA;  80997 MW;  5F13573F47ECDAA8 CRC64;
     MILKSHLFRV IPDPDPLTLR PNVETIKCVV VGDNAVGKTR LICARACNAT LTQYQLLATH
     VPTVWAIDQY RVCQEVLERS RDVVDDVSVS LRLWDTFGDH HKDRRFAYGR SDVVVLCFSI
     ANPNSLYHVK TMWYPEIKHF CPRAPVILVG CQLDLRYADL EAVNRARRPL ARPIKSNEIL
     PPERGREVAK ELGVPYYETS VVAQFGVKDV FDNAIRAALI SRRHLQFWKS HLRNVQRPLL
     QAPFLPPKPP PPLITVPPPP TTTEEHPVGL LEDPHCADVI LVLQERQKIF AHKIYLATSS
     SKFYDLFILD VQNAASERPA RAPLSGRELL MRAASFDVCE SNDDGDRANL RACTSDGTLK
     DFEGSRRGRM LSSWSRAFVS IQEELVEDPV TYGPRPMTVV HMDQSMQLGP FRAVLRYLYT
     GQLDENEKEL MHIAHIAELL EVFDLRMMVA NILNNEAFMN QEITKAFHVR RTNRVKECLA
     KGTFSDVVFK LDDGTIMAHK PLLISSCDWM AAMFGGPFVE SCTKEVLFPN TSRSSMRAVL
     EYLYTGRFCS RPDLDAMELI VLANRLCLPH LVALTELYTV TVLTEAAMMG TDIDGDVLLY
     LDMAQFHGAQ QLTGWCLHHI CTNYNSICRK FPRDMKAKSA DNQEYFEKHR WPPVWYLKED
     DHYQRARRER DKEDYLYQRR QCKRKWLFWN LPSSPSSHSP SSGSSAVI
//