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Database: UniProt
Entry: H2SUM4_TAKRU
LinkDB: H2SUM4_TAKRU
Original site: H2SUM4_TAKRU 
ID   H2SUM4_TAKRU            Unreviewed;      1830 AA.
AC   H2SUM4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   20-JUN-2018, entry version 43.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000016111, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000016111}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000016111}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   Ensembl; ENSTRUT00000016183; ENSTRUP00000016111; ENSTRUG00000006562.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    100    117       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    138    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    171    191       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    226    248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    302    323       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    335    357       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    490    509       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    615    637       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    693    715       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1098   1116       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1136   1156       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1168   1187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1233   1255       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1345   1370       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1426   1444       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1456   1478       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1547   1565       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1636   1659       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1796   1830       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      711    738       {ECO:0000256|SAM:Coils}.
FT   COILED     1045   1065       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1830 AA;  208279 MW;  487C5511236B46D7 CRC64;
     MARFAEDLPT RYGGSAGGGG RGGPGTGRGG ARAGGAAPGG QRVYKQSMAQ RARTMAIYNP
     NPVKQNCLTV NRSLFIFRED NLIRKYAKRI TEWPYLYTPF EYMILATIIA NCIVLALEQH
     LPASDKTPMS ERLDDTEPYF IGIFCFEAAI KIIALGFAFH KGSYLRNGWN VMDFVVVLSG
     ILATVGSDFD LRTLRAVRVL RPLKLVSGIP SLQVVLKSIM KAMVPLLQIG LLLFFAIVMF
     AIIGVEFYMG KFHTTCFRTD TGEKAADWSC GQEPPARICP NGTECREYWT GPNFGITNFD
     NILFAILTVF QCITMEGWVD ILYSTNNVAG NTWNWLYFIP LIIIGSFFML NLVLGVLSGE
     FAKERERVEK RQEFLKLRRQ QQIERELTGY LEWICKAEEV LLEEEDEIAD EKSPLDVLKR
     NKAKKGKNDL IGAEEGEDPF ADISSVAPPG SPFGRASVKS SGKMDSSSYF RRKEKRVRFF
     IRRMVKAQSF YWIVLCVVGL NTLCVAIVHY DQPEWLTKAL YTAEFVFLGL FLTEMTLKMY
     GLGVRNYFHS SFNCFDFGVI VGSICEVIWD MITPGASFGI SVLRALRLLR IFKVTKYWNS
     LRNLVISLLN SMKSIISLLF LLFLFIVVFA LLGMQLFGGQ FNFEDETPTT NFDTFPAAIL
     TVFQILTGED WNAVMYHGIE SQGGVRRGMF SSVYFIVLTL FGNYTLLNVF LAIAVDNLAN
     AQELTKDEEE QEEAANKKLA LQKALEVKEV SPMSAANISI AAKEQQRTAK TMSVWEQRTN
     QLRRHNMRAS SEALFNELDP EERRRMSTAL HLHPDMKTHL DRPLIVEDRG GDKPARTPDR
     SRDHNGNGSQ SKERRGERSH SRNGGQGHRH HHHHHNGSPE EEANDVRGGE ERVHRHHHSH
     RPPKEGNGTI ANGSQGDRKA GRGWRRLQEE QKRKPKSLVK TLSCSYQLDA FWRERLEAES
     DHVCDEINIS LPREKTPDAQ EDGLASTPLQ AMRGGLTAGE KQEDADNLKN STRASQAGLN
     SNAIHIPVTI TAPPGETTLI PMNNIDCESF QIREEKKNLE EAEEVNGPRQ MLPYSSMFIF
     GQTNPVRRLC HYVVNLRYFE MCILIVITMS SIALAAEDPV QANAPRNNVL KYLDYVFTGV
     FTFEMVIKMI DLGLLLHPGS YFRDLWNILD FIVVSGALVA FACSSLMGGT KGKDINTIKS
     LRVLRVLRPL KTIKRLPKLK AVFDCVVNSL KNVLNILIVY ILFMFIFAVI AVQLFKGKFF
     YCTDESKVLE KDCRGHFLEY DKDHVTAQPR EWKKYDFHYD NVLWAFLTLF TVSTGEGWPM
     VLKHSVDATY EDQGPNPGFR METSIFYVVY FVVFPFFFVN IFVALIIITF QEQGDKAMSE
     CSLEKNERAC IDFAINAKPL TRYMPENKLS FQYKMWKFVV SPPFEYAIMT LIALNTVVLM
     MKFYGAPDLY ESMLKYLNIV FTALFTLECI LKIIAFGPLN YLKAAWNVFD FVTVLGSITD
     ILVTEVKDKM INLSFLRLFR AARLIKLLRQ GYTIRILLWT FVQSFKALPY VCLLIAMLFF
     IYAIIGMQVF GNIELIEESA IHRHNNFQTF FQALTLLFRS ATGEAWHEIM LACLSNRPCD
     KLSGTVGNEC GSDFAYFYFV SFIFLCSFLM LNLFVAVIMD NFEYLTRDAS ILGPHHLDEF
     IRVWAEYDPA ACGRICYQDM YKLLLFISPP LGLGKKCPNR VAYKRLVKMN MPIADDNTVH
     FTSTLMALIR TALEIKLASG VLVQRLYDAD LKREISRVWP SLPQKTIDLL VTPHKYNELT
     VGKVYAALMI FDYYKQNRAK RLQQQQQSST
//
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