ID H2SVF2_TAKRU Unreviewed; 1064 AA.
AC H2SVF2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=SLIT-ROBO Rho GTPase activating protein 1 {ECO:0000313|Ensembl:ENSTRUP00000016390.3};
GN Name=SRGAP1 {ECO:0000313|Ensembl:ENSTRUP00000016390.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000016390.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000016390.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000016390.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2SVF2; -.
DR STRING; 31033.ENSTRUP00000076243; -.
DR Ensembl; ENSTRUT00000016462.3; ENSTRUP00000016390.3; ENSTRUG00000006667.3.
DR GeneTree; ENSGT00950000182824; -.
DR Proteomes; UP000005226; Chromosome 9.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04383; RhoGAP_srGAP; 1.
DR CDD; cd11955; SH3_srGAP1-3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035648; srGAP1/2/3_SH3.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR14166:SF15; SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 22..312
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 462..652
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 701..760
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 768..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..791
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..879
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1054
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1064 AA; 121235 MW; 5176096D813DB90D CRC64;
RGNPTHLKPH KEPLGVICLH ILPIRAQLVE QQKCLDQQTD MRVQLLQDLQ DFFRKKSEIE
MEYSRNLEKL AERFMAKTRS TKDHQQYKDQ NLLSPVNCWY LLLNQVRRES KDHATLSDIY
LNNVIMRFMQ ISEDSTRLLK KSKEIAFQLQ EDLMKVLNEL YTVMKTYHMY HSESISAESK
LKEAEKQEEK QIGRGDQVFS IRMEDKYQRR SSVKKIEKMK EKRQAKYSEN KLKSIKARNE
YLLTLEASNS SLFKYYIHDL SDLIDCCDLG YHASLNRALR TYLSAEYNLE TSRHEGLDII
ENAVDSLDPR SDRQRFMEMY PTAFCPPAKF EFQSHMGDEV CQISLQPPVN GELILRFQQL
QSRLATLKIE NEEIKKTSEA TLTTIQDMVT IEDYDVSECF HHSRSTESVR STVSETYLSK
PSIAKRRANQ QETEQFYFMK FREYLEGSNL ISKLQAKHDF RGRRNSHTRH QDSGQAIPRV
VESCIRYINL YGLQHQGIFR VSGSQLEVND IKNSFERGND PLTDDESNHD INSVAGVLKL
YFRGLENPLF PKERFNDLLA CIRIENLYER ALYIRKILLT IPRSVLIVMR YLFAFLNHLS
QYSDENMMDT YNLAICFGPT LMPTPESQDQ VSCQAHVNEI IKTIIIHHET IFPDTKELDG
PVYEKCMAGG DYCESPFSEH GALEEVENEG GTETHTSEDE GEPIEAIAKF DYVGRSSREL
SFKKGASLLL YQRASEDWWE GRHNGIDGLV PHQYIVVQDV DDNFSDTLSQ KADSEASSGH
TGEDRCSGKD MAPPTDTRIS EAYITSRHKK RSDPPSRRPP ACPGEVHCMV HPSQHGHGGH
GGTPELGSPV ISHFSPRDMR RTHNHVSTDS PERRRRTGHG SLNNISRHES LKKMESPPIR
RSTSSGQYTG FTDVHRHHSG KALDPETIAQ DIEETMNTAL NELRELERQS SAKHAPDVVL
DTLEQRQTSG GGSGGGPTPA SSGDSLSPIH GVMLRSTANT EPPIRRSISS TSDTMSTFKP
VVAPRMGVQL KPPALRPKPL VVPKSSPAPQ PPAPQDAQDK SCTM
//
