ID H2SWC2_TAKRU Unreviewed; 1242 AA.
AC H2SWC2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Proline-, glutamic acid- and leucine-rich protein 1 {ECO:0000256|ARBA:ARBA00018417};
DE AltName: Full=Modulator of non-genomic activity of estrogen receptor {ECO:0000256|ARBA:ARBA00030054};
GN Name=LOC101071127 {ECO:0000313|Ensembl:ENSTRUP00000016710.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000016710.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000016710.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000016710.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RIX1/PELP1 family.
CC {ECO:0000256|ARBA:ARBA00010511}.
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DR RefSeq; XP_011604819.1; XM_011606517.1.
DR AlphaFoldDB; H2SWC2; -.
DR STRING; 31033.ENSTRUP00000016710; -.
DR Ensembl; ENSTRUT00000016783.3; ENSTRUP00000016710.2; ENSTRUG00000006803.3.
DR GeneID; 101071127; -.
DR KEGG; tru:101071127; -.
DR CTD; 27043; -.
DR GeneTree; ENSGT00940000167512; -.
DR HOGENOM; CLU_007599_1_0_1; -.
DR InParanoid; H2SWC2; -.
DR OMA; DFIACPP; -.
DR OrthoDB; 3090187at2759; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012980; PELP1_middle.
DR InterPro; IPR012583; RIX1_N.
DR PANTHER; PTHR34105; PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1; 1.
DR PANTHER; PTHR34105:SF1; PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1; 1.
DR Pfam; PF08166; PELP1_HEAT; 2.
DR Pfam; PF08167; RIX1; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 20..194
FT /note="Pre-rRNA-processing protein RIX1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08167"
FT DOMAIN 391..445
FT /note="PELP1 middle"
FT /evidence="ECO:0000259|Pfam:PF08166"
FT DOMAIN 546..616
FT /note="PELP1 middle"
FT /evidence="ECO:0000259|Pfam:PF08166"
FT REGION 885..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..909
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..990
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1061
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1163..1177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1242 AA; 133113 MW; E6F7ECC7C628F55F CRC64;
MATSAWLRGP SAMRLTEGLV SVLKEQRPDY IPVLLTGYRE HGVFHTQGAS AVAGLVGFSN
AKLGSSKTRF EGLCLLSMLV KDSSSDLFQQ HCLSWLRSLQ QIVQSQAPVQ TIQLAVNILK
DVLQYSSQIP ELAREVGLNS ILGILTSLLG LKTECELAAM EGMTACMTHY PRACGSLKDK
LGAYFLSKMD STNKKTQEMA CQCYAHLPCL GGVLDRGAGA GRAEGWTNQI HCLLASANSH
LALIYQGAEM EGTMQYEGPG VELAFPLLDQ SDPLFLLQLQ HRFTAVCLAL RHTLRVDPAS
AVRIPVRPIL NLVCRALAVS CKSFNLTGDG NVRLLILPII HLNILEVLAA LIIAVRSSMV
QYAAVLQRLF SQTLSAWTPA AEASVGQQRA FSSVRVSVYR TLELWLQVAG ASTSILHGSP
NHSEILFNHL LSDITPGAES VKLRVGLSAE IVPGGKPGPR RTKSLVISDT VGPSLQRKGD
IMANQDTCLT ALRALRQIIL VSGTLLKDDI HKRLHDVLLP LCVRLQQQQL SSNMSCDSTA
GISGQYSSAL TRRELYRLLL ALVLVPSPCW PPPLTCVVSI LSSGRTDRNL KVSTFCCEAL
TVCNSLLHPR SPSIALPMPP LSIKPAHAVS VLPTPQASTP GLTLPTLLGE PTPPPPFPSP
HTLGMGPSSL LGSLENHLSL VPGLRGQTSG PSEMILSPHA HHQDLAGLGP PEGQRPVFVR
YDREEAEDVE ISLASDSDDS VVIVPPGMLN MENQQDDVAA ANSQSMTAAA GGAAVTLAEG
EPVTMVPNTA TAAPIDGVSL PNDLTTSAPL LTTSAPPINS FPPSSASVVS LVPALNSNPL
TAPPGGLVEP IPSRPQLQQM LMQPSAAVQQ GPLSLPLQIH QLQSQLGQQG RPLQQQPPVA
SNEDSGVINI NSTDDEEDDE DMEDDEEEEE EEGVEDEEEE EDEVSSFADE EFFEDYEEFE
YDAEELEEED EEEGDIPPLE GAEEQGEQEE VEQGGVLQAA VEAAEIVDFS VEGEAGGGIE
EIQTKRALFP EDRMKVQEVE SIGVMEEARG EAEEDETERV CDPTMPQILC VTGGALEEKE
EEGGRVQEDM SSWERDAKKV EPQGPSGEAA ASTAEQEESG GEQQAGSSEE RPSSLGEEQE
VTVSEEDAAL THPGGSDEST PEPQETVTEK REAAAAAEQQ ELHAGGGEEG KGVKRKREEL
QSENELEGSS KQADEDTMAS MLADFVACPP DDDDGPSASN QS
//
