ID H2SX79_TAKRU Unreviewed; 631 AA.
AC H2SX79;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN Name=LOC101068485 {ECO:0000313|Ensembl:ENSTRUP00000017017.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000017017.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000017017.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000017017.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_003970795.1; XM_003970746.2.
DR AlphaFoldDB; H2SX79; -.
DR STRING; 31033.ENSTRUP00000017017; -.
DR Ensembl; ENSTRUT00000017090.3; ENSTRUP00000017017.3; ENSTRUG00000006928.3.
DR GeneID; 101068485; -.
DR KEGG; tru:101068485; -.
DR CTD; 30141; -.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000164418; -.
DR InParanoid; H2SX79; -.
DR OMA; SECVRHP; -.
DR OrthoDB; 5475408at2759; -.
DR TreeFam; TF351835; -.
DR Proteomes; UP000005226; Chromosome 15.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0021536; P:diencephalon development; IEA:Ensembl.
DR GO; GO:0030901; P:midbrain development; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24044:SF308; DELTA-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 6.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 6.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 8.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..631
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025505023"
FT TRANSMEM 518..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 156..200
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 267..305
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 307..343
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 345..382
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 384..420
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 422..458
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 460..496
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 158..167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 171..183
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 191..200
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 295..304
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 333..342
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 372..381
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 410..419
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 448..457
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 486..495
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 631 AA; 69463 MW; 99A5CFF16B75E931 CRC64;
MAHIHVTCLL TLAFVHVVFS SGVFELKIHS FHTAQRICRR HRDCHIFFRI CLKHPEDVIS
AEPPCTFGTG HTNVIRADRT SISSSAPIKV PFHFKWPGTF SLIIEAWNTE SPTEYTDNQN
NLVSRLATKR RLAIGEDWSQ DVHFGEQSEL RYSYHVFCDE FYFGDGCADY CRPRDDTLGH
YTCDEEGNRI CLEGWKGNYC SEPICSADCS EKHGYCEAPG GCTCRMGWQG PSCTECVRYP
GCLHGTCSQP WQCNCQEGWG GLFCDQDLNY CTNHKPCANG ATCTNTGQGS YTCACRPGFG
GTNCELETNE CDSNPCKNGG SCNDLENDYS CTCPQGFYGK NCEIIAMTCA DGPCFNGGTC
VETMTGGYTC RCPPSYTGSN CEKKLDRCSN RPCLNGGQCL DLGQSVLCRC RPGFTGANCQ
VNIDDCASAP CQNAGTCQDG LNDYTCSCTL GYTGKNCSVR SDACGERPCQ NGGTCFTHFT
GPVCQCPKGF MGPSCEFTLQ SSFKPALRQT SHHSSTTITI SCILTVLLLV LVVGVIFMRR
RRTQQGRKQL REIAVYNDLE TVNNLGGSER EAFLSPNGLF KISNSTARLS LTLCPDGRSG
YRHNPAESNQ ARGERHDFMW RDEAGLSSAL R
//
