ID   H2SXA6_TAKRU            Unreviewed;       885 AA.
AC   H2SXA6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=P53-induced death domain protein 1 {ECO:0000313|Ensembl:ENSTRUP00000017044.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000017044.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000017044.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000017044.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; H2SXA6; -.
DR   STRING; 31033.ENSTRUP00000017044; -.
DR   Ensembl; ENSTRUT00000017117.3; ENSTRUP00000017044.3; ENSTRUG00000006941.3.
DR   eggNOG; KOG0619; Eukaryota.
DR   eggNOG; KOG4177; Eukaryota.
DR   GeneTree; ENSGT00940000166188; -.
DR   HOGENOM; CLU_017883_0_0_1; -.
DR   InParanoid; H2SXA6; -.
DR   OMA; HRDNLGA; -.
DR   TreeFam; TF331183; -.
DR   Proteomes; UP000005226; Chromosome 9.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 2.60.220.30; -; 2.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR48051; -; 1.
DR   PANTHER; PTHR48051:SF1; ZGC:77287; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 6.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS51450; LRR; 1.
DR   PROSITE; PS51145; ZU5; 1.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          439..577
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
FT   DOMAIN          766..852
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   885 AA;  98011 MW;  321E656BCBF6656A CRC64;
     MEKGNHEGEG RDEIHREQSD VTTDGPGLRF PGLLNDQAQE KSSRLRSQGQ TKDMDEESDA
     LTSVLADTRL TLDVYKGGAA ALPLLWASIP EQLMGVQYLT VGSEDKAGLD DALDVIPNLT
     DLHTLTIRGH RFYDAQGDPL PGLLTTLPMS FSCLSQLVHL DLSFNQLSCV PPCLLGLPTL
     SSLLLCQNRI SELPSDVGQL SSLTYLSLLG NKLITLPPSL GQLSGLRTLD VSLNLLQRLP
     DEIGSLGGLV KLELSQNKLR QLPESMGSLS SLRELFIYSN DIRVVPPCLN KLPLLKIDMR
     GNPLGRPPTP PPLPPVPAVI YTAVLLLLFS FCVSPAGCHV FLPGGAELLF PPGCLLTTTR
     LEWVEKTPEK TLVHLEEHEI LLSCPLELRP HGIKFFKVRI ERTEVVVQRF DGFSWSTLPT
     VLRRGLRQFS WFMVVSRPVK DSCSLTSAGT LLVSSADPGI KLHFPPDSTL ENRTVTLQVS
     AAEIQVLCGD PQARVSPLLC LSQNPSTDFL QPVKVQVPLP PGVTGAVSDM SCLHLLHGDP
     AAQSWTDITS QVSLYVTHVY AIFYITHFSW YWLWYTTQRI VCGTVRKVYQ KLKQFKVQFL
     VLQRKTDPSQ VILQCLPSNK VDNRVQSLAE LYDGPQPSDM CDLLEGEQFF AGFERGLDIS
     TERPDCVEGR LCFVFYSSLK NLKEVYICAV EGHTGPVRGQ VSFYRGEIPG DLPEELARKR
     KGHDNQWLAT LPVKLPVRDN SENGFLVENS QHPPLNLGDP ESGYLTESNL LSISLQIGQD
     WRVVGINLGL SYEELDRIQY KSRDNLGALV LDMLFHWARG QRRAGPGAVS RLVSAMIESG
     RRDLADEIED TVRIGRRKYS ESLKRVGILG LRDQIGLCGR AQAGL
//