ID H2SXB2_TAKRU Unreviewed; 520 AA.
AC H2SXB2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Membrane palmitoylated protein 2 {ECO:0000313|Ensembl:ENSTRUP00000017050.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000017050.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000017050.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000017050.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR AlphaFoldDB; H2SXB2; -.
DR STRING; 31033.ENSTRUP00000017050; -.
DR Ensembl; ENSTRUT00000017123.3; ENSTRUP00000017050.3; ENSTRUG00000006945.3.
DR eggNOG; KOG0609; Eukaryota.
DR GeneTree; ENSGT00940000155348; -.
DR HOGENOM; CLU_001715_5_1_1; -.
DR InParanoid; H2SXB2; -.
DR OMA; DTLKGMH; -.
DR TreeFam; TF314263; -.
DR Proteomes; UP000005226; Chromosome 12.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd11862; SH3_MPP; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR PANTHER; PTHR23122:SF45; PROTEIN PALS2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 53..111
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 134..213
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 219..287
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 318..505
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
SQ SEQUENCE 520 AA; 57883 MW; F2B61FA60A326F65 CRC64;
RSEIKTNSFS MQQVLDNAGE APASSGAKDI DLLFLRGIME SPTAHEHTEE VKLEAVQDNN
VELVTEILGD ISSLKVKDDS AAELSRILQE PHFQSLLEAH DIVASKCYEV PPPPEMSNDA
AVNSALMQAD AVRMIGIRKK AGEPLGVTFR VEKDDLVIAR ILHGGMIDRQ GLLHVGDIIK
EVNGKDVGNN PTELQDMLKD CSGGITLKIL PSYRDAPAPP QVYVRPYFDY NPANDSLIPC
REAGMAFTKG DILQIVNRED PNWWQACHVV GGATGLIPSQ FLEEKRKAFV PRDFEGAEFD
RHELQIYEEV AKVPAFQRKT LVLIGAQGVG RRSLKNRLMV LHPTRFGTTI PYTSRRPRDN
ELNGNTYHFT TRSEMEVDVK AGRFLEHGEY DGNLYGTKIE SIHEVVAAGR TCILDVNPQA
LKVLKTAEFM PYVVFVAAPD FDTLKAMHKA VVDAGITTKQ LTDVDLRKTV DESARIQRAY
GHYFDLTIVN DNLDKAFETL QVAVDGLCSD PQWVPVNWVY
//
